Atherosclerosis is a chronic inflammatory disease of the arterial wall and the primary
underlying cause of cardiovascular disease. Data from in vivo imaging, cell-lineage tracing …

Abstract COVID-19, caused by SARS-CoV-2, is the most consequential pandemic of this
century. Since the outbreak in late 2019, animal models have been playing crucial roles in …

Atherosclerosis is a progressive vascular disease triggered by interplay between abnormal
shear stress and endothelial lipid retention. A combination of these and, potentially, other …

Atherosclerosis, a chronic inflammatory disorder of the arteries, is responsible for most
deaths in westernized societies with numbers increasing at a marked rate in developing …

The transforming growth factor-β (TGFβ) superfamily is encoded by 33 genes and includes
TGFβ, bone morphogenetic proteins (BMPs) and activins. Although TGFβ is well recognized …

Genetic studies in animals and humans indicate that gene mutations that functionally perturb
transforming growth factor β (TGF-β) signaling are linked to specific hereditary vascular …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Immune cells were traditionally considered as major pro-inflammatory contributors. Recent
advances in molecular immunology prove that immune cell lineages are composed of …

Cardiovascular disease (CVD) is the number one cause of death in the United States and
worldwide. The most common cause of cardiovascular disease is atherosclerosis, or …

Cardiovascular disease is the leading cause of mortality worldwide, and atherosclerosis the
principal factor underlying cardiovascular events. Atherosclerosis is a chronic inflammatory …