Osteoarthritis is thought to be the most prevalent chronic joint disease. The incidence of
osteoarthritis is rising because of the ageing population and the epidemic of obesity. Pain …

Subchondral bone and the synovium play an important role in the initiation and progression
of OA. MRI often permits an early detection of synovial hypertrophy and bone marrow …

Background: The purpose of this study was to determine the clinical opportunities for the use
of computed tomography (CT) imaging for inferring bone quality and to critically analyze the …

Excessive joint surface loadings, either single (acute impact event) or repetitive (cumulative
contact stress), can cause the clinical syndrome of osteoarthritis (OA). Despite advances in …

Joint distraction, the prolonged mechanical separation of the bones at a joint, has emerged
as a joint-preserving treatment for end-stage osteoarthritis, with the gradually growing …

Background Treatment of severe osteoarthritis (OA) in relatively young patients is
challenging. Although successful, total knee prosthesis has a limited lifespan, with the risk of …

Objective Mechanical joint loading is critical for the development of osteoarthritis (OA).
Although once regarded as a disease of cartilage attrition, OA is now known to be controlled …

In this Review we describe three approaches for cartilage tissue repair at the rheumatology–
orthopaedics interface: disease-modifying osteoarthritis (OA) drug (DMOAD) treatment; cell …

Objective Surgical knee joint distraction (KJD) leads to clinical improvement in knee
osteoarthritis (OA) and also apparent cartilage regeneration by magnetic resonance …

Objective Both, knee joint distraction (KJD) and high tibial osteotomy (HTO) are joint-
preserving surgeries that postpone total knee arthroplasty (TKA) in younger osteoarthritis …