[HTML][HTML] Cancer takes many paths through G1/S

ES Knudsen, AK Witkiewicz, SM Rubin - Trends in Cell Biology, 2024 - cell.com
In the commonly accepted paradigm for control of the mammalian cell cycle, sequential
cyclin-dependent kinase (CDK) and cyclin activities drive the orderly transition from G1 to S …

[HTML][HTML] Key Proteins of Replication Stress Response and Cell Cycle Control as Cancer Therapy Targets

AI Khamidullina, YE Abramenko, AV Bruter… - International Journal of …, 2024 - mdpi.com
Replication stress (RS) is a characteristic state of cancer cells as they tend to exchange
precision of replication for fast proliferation and increased genomic instability. To overcome …

Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian …

T Kader, JR Lin, C Hug, S Coy, YA Chen, I de Bruijn… - bioRxiv, 2024 - biorxiv.org
High-Grade Serous Ovarian Cancer (HGSOC) originates from fallopian tube (FT) precursors.
However, the molecular changes that occur as precancerous lesions progress to HGSOC …

Bevacizumab and conventional chemotherapy for the treatment of epithelial ovarian cancer: a systematic review of the literature, best evidence synthesis and …

C Silotch - 2024 - escholarship.mcgill.ca
Epithelial Ovarian Carcinoma (EOC) is one of the most common gynecologic malignancies
diagnosed in women, consistently ranking among the top 5 leading causes of cancer death …