The structure and function of the barrier layers restricting the free diffusion of substances
between the central nervous system (brain and spinal cord) and the systemic circulation is of …

Our brain serves as a center for cognitive function and neurons within the brain relay and
store information about our surroundings and experiences. Modulation of this complex …

Hepatocytes, like other epithelia, are situated at the interface between the organism's
exterior and the underlying internal milieu and organize the vectorial exchange of …

ZO-1, ZO-2 and ZO-3 are tight junction (TJ)-associated proteins that belong to the MAGUK
family. In addition to the presence of the characteristic MAGUK modules (PDZ, SH3 and GK) …

Tight junctions (TJ) of polarized epithelial cells regulate barrier function at mucosal surfaces.
Structural proteins of TJs include hyperphosphorylated occludin (HO) and the peripheral …

Yeaman, Charles, Kent K. Grindstaff, and W. James Nelson. New Perspectives on
Mechanisms Involved in Generating Epithelial Cell Polarity. Physiol. Rev. 79: 73–98, 1999 …

Polarized epithelial cells separate two extremely different cellular milieus. The tight junction
(TJ) is the most apical component of the junctional complex and serves as the permeability …

High-intensity focused ultrasound (HIFU) has been shown to generate lesions that destroy
brain tissue while disrupting the blood-brain barrier (BBB) in the periphery of the lesion. BBB …

Of 11 genes involved in nonspecific X-linked mental retardation (MRX), three encode
regulators or effectors of the Rho GTPases, suggesting an important role for Rho signaling in …

The blood–brain barrier (BBB) is a structural and functional barrier that regulates the
passage of molecules into and out of the brain to maintain the neural microenvironment. We …