Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation
in joints, associated with synovial hyperplasia and with bone and cartilage destruction …

Recent years have seen considerable advances in our understanding of both the clinical
and basic-research aspects of rheumatoid arthritis. Clinical progress has come from a better …

Rheumatoid arthritis (RA) is one of the most prevalent autoimmune diseases and a
prototypic inflammatory disease, affecting the small joints of the hands and feet. Chemokines …

Cytokines and chemokines represent two important groups of proteins that control the
human immune system. Dysregulation of the network in which these immunomodulators …

Chemokines and their receptors direct leukocyte migration among blood, lymph and tissues.
Evidence has recently accumulated that, besides their chemotactic functions, chemokine …

Rheumatoid arthritis (RA) is a chronic inflammatory disease leading to joint destruction (1).
In RA, migration of leukocytes into the synovial tissue (ST) occurs. These leukocytes and …

Background: Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory disease that
affects approximately 0.5–1% of adults worldwide and commonly results in joint destruction …

The traffic of the different types of immune cells is an important aspect in the immune
response. Chemokines are soluble peptides that are able to attract cells by interaction with …

The host response to intracellular pathogens requires the coordinated action of both the
innate and acquired immune systems. Chemokines play a critical role in the trafficking of …

Chemokine receptors play a key role in directing the migration of inflammatory cells into
various injured or infected organs. However, migration of inflammatory cells into tissues can …