Stereoselective synthesis and applications of spirocyclic oxindoles
AJ Boddy, JA Bull - Organic Chemistry Frontiers, 2021 - pubs.rsc.org
The development of novel synthetic strategies to form new chemical entities in a
stereoselective manner is an ongoing significant objective in organic and medicinal …
stereoselective manner is an ongoing significant objective in organic and medicinal …
New development in the enantioselective synthesis of spiro compounds
A Ding, M Meazza, H Guo, JW Yang… - Chemical Society Reviews, 2018 - pubs.rsc.org
The enantioselective synthesis of spirocycles has long been pursued by organic chemists.
Despite their unique 3D properties and presence in several natural products, the difficulty in …
Despite their unique 3D properties and presence in several natural products, the difficulty in …
Catalytic asymmetric synthesis of spirooxindoles: recent developments
GJ Mei, F Shi - Chemical Communications, 2018 - pubs.rsc.org
Chiral spirooxindoles are privileged heterocyclic motifs, which are widely found in natural
alkaloids and pharmaceuticals. Moreover, the construction of chiral spiro-cyclic frameworks …
alkaloids and pharmaceuticals. Moreover, the construction of chiral spiro-cyclic frameworks …
Catalytic enantioselective construction of spiro quaternary carbon stereocenters
PW Xu, JS Yu, C Chen, ZY Cao, F Zhou, J Zhou - ACS Catalysis, 2019 - ACS Publications
The catalytic enantioselective assembly of spirocyclic molecules featuring a spiro quaternary
carbon stereocenter is currently of great interest because such privileged 3D structures are …
carbon stereocenter is currently of great interest because such privileged 3D structures are …
Bifunctional amine‐squaramides: powerful hydrogen‐bonding organocatalysts for asymmetric domino/cascade reactions
P Chauhan, S Mahajan, U Kaya… - … Synthesis & Catalysis, 2015 - Wiley Online Library
Organocatalytic domino/cascade reactions provide a convenient method for the construction
of complex molecular structures bearing multiple stereocenters in a highly stereoselective …
of complex molecular structures bearing multiple stereocenters in a highly stereoselective …
Recent advances in the synthesis of biologically active spirooxindoles
MMM Santos - Tetrahedron, 2014 - Elsevier
The spirooxindole system is the core structure of a variety of medicinal agents and natural
products. 1, 2 In fact, spirooxindole derivatives have been described with different biological …
products. 1, 2 In fact, spirooxindole derivatives have been described with different biological …
Organocatalytic Domino Oxa‐Michael/1, 6‐Addition Reactions: Asymmetric Synthesis of Chromans Bearing Oxindole Scaffolds
K Zhao, Y Zhi, T Shu, A Valkonen… - Angewandte …, 2016 - Wiley Online Library
An asymmetric organocatalytic domino oxa‐Michael/1, 6‐addition reaction of ortho‐
hydroxyphenyl‐substituted para‐quinone methides and isatin‐derived enoates has been …
hydroxyphenyl‐substituted para‐quinone methides and isatin‐derived enoates has been …
Squaramide equilibrium acidities in DMSO
A number of popular squaramide organocatalysts' acidities were determined by an
overlapping indicator method in DMSO via UV spectrophotometric titrations. The p K a …
overlapping indicator method in DMSO via UV spectrophotometric titrations. The p K a …
Diastereo‐and Enantioselective Construction of a Bispirooxindole Scaffold Containing a Tetrahydro‐β‐carboline Moiety through an Organocatalytic Asymmetric …
W Dai, H Lu, X Li, F Shi, SJ Tu - Chemistry–A European …, 2014 - Wiley Online Library
The first catalytic asymmetric construction of a new class of bispirooxindole scaffold‐
containing tetrahydro‐β‐carboline moiety has been established through chiral phosphoric …
containing tetrahydro‐β‐carboline moiety has been established through chiral phosphoric …
Recent advances in organocatalytic cascade reactions toward the formation of quaternary stereocenters
This review provides the authors' selection of recent publications that highlight the
increasing efforts to develop valuable organocatalytic domino/tandem/cascade reactions as …
increasing efforts to develop valuable organocatalytic domino/tandem/cascade reactions as …