Calcium handling by mitochondria is a key feature in cell life. It is involved in energy
production for cell activity, in buffering and shaping cytosolic calcium rises and also in …

The sarcoplasmic reticulum (SR) of smooth muscles presents many intriguing facets and
questions concerning its roles, especially as these change with development, disease, and …

The endoplasmic reticulum (ER) and mitochondria accumulate Ca2+ within their lumens to
regulate numerous cell functions. However, determining the dynamics of intraorganellar …

Optical Ca 2+ indicators are powerful tools for investigating intracellular Ca 2+ signals in
living cells. Although a variety of Ca 2+ indicators have been developed, deciphering the …

We describe the generation of a family of high‐signal‐to‐noise single‐wavelength
genetically encoded indicators for maltose. This was achieved by insertion of circularly …

Quantitative analysis of Ca2+ fluctuations in the endoplasmic/sarcoplasmic reticulum
(ER/SR) is essential to defining the mechanisms of Ca2+-dependent signaling under …

Small, fluorescent, calcium-sensing molecules have been enormously useful in mapping
intracellular calcium signals in time and space, as chapters in this volume attest. Despite …

Genetically encoded calcium indicators (GECIs) allow researchers to measure calcium
dynamics in specific targeted locations within living cells. Such indicators enable dissection …

The past several decades of research into calcium signaling have focused on intracellular
calcium (Cai2+), revealing both exquisite spatial and dynamic control of this potent second …

Calcium in interstitial fluids is central to systemic physiology and a crucial ion pool for entry
into cells through numerous plasma membrane channels. Its study has been limited by the …