Parkinson's disease: Mechanisms, translational models and management strategies

C Raza, R Anjum - Life sciences, 2019 - Elsevier
Parkinson's disease is a progressive neurodegenerative disorder. The classical motor
symptoms include resting tremors, bradykinesia, rigidity and postural instability and are …

[HTML][HTML] Parkinson's disease: biomarkers, treatment, and risk factors

FN Emamzadeh, A Surguchov - Frontiers in neuroscience, 2018 - frontiersin.org
Parkinson's disease (PD) is a progressive neurodegenerative disorder caused mainly by
lack of dopamine in the brain. Dopamine is a neurotransmitter involved in movement …

Towards fog-driven IoT eHealth: Promises and challenges of IoT in medicine and healthcare

B Farahani, F Firouzi, V Chang, M Badaroglu… - Future generation …, 2018 - Elsevier
Abstract Internet of Things (IoT) offers a seamless platform to connect people and objects to
one another for enriching and making our lives easier. This vision carries us from compute …

[HTML][HTML] Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments

P Maiti, J Manna, GL Dunbar - Translational neurodegeneration, 2017 - Springer
Gradual degeneration and loss of dopaminergic neurons in the substantia nigra, pars
compacta and subsequent reduction of dopamine levels in striatum are associated with …

[HTML][HTML] Initiation and propagation of α-synuclein aggregation in the nervous system

BA Hijaz, LA Volpicelli-Daley - Molecular neurodegeneration, 2020 - Springer
The two main pathological hallmarks of Parkinson's disease are loss of dopamine neurons
in the substantia nigra pars compacta and proteinaceous amyloid fibrils composed mostly of …

Quantitative susceptibility mapping (QSM): decoding MRI data for a tissue magnetic biomarker

Y Wang, T Liu - Magnetic resonance in medicine, 2015 - Wiley Online Library
In MRI, the main magnetic field polarizes the electron cloud of a molecule, generating a
chemical shift for observer protons within the molecule and a magnetic susceptibility …

[HTML][HTML] Closed-loop stimulation of temporal cortex rescues functional networks and improves memory

Y Ezzyat, PA Wanda, DF Levy, A Kadel, A Aka… - Nature …, 2018 - nature.com
Memory failures are frustrating and often the result of ineffective encoding. One approach to
improving memory outcomes is through direct modulation of brain activity with electrical …

[HTML][HTML] Parkinson's disease: A review

DM Radhakrishnan, V Goyal - Neurology India, 2018 - journals.lww.com
Parkinson's disease is a common movement disorder seen in neurological practice, but the
diagnosis and management is challenging. The diagnosis is clinical and sometimes difficult …

Parkinson disease

W Poewe, K Seppi, CM Tanner, GM Halliday… - Nature reviews Disease …, 2017 - nature.com
Parkinson disease is the second-most common neurodegenerative disorder that affects 2–
3% of the population≥ 65 years of age. Neuronal loss in the substantia nigra, which causes …

[HTML][HTML] Deep brain stimulation programming for movement disorders: current concepts and evidence-based strategies

T Koeglsperger, C Palleis, F Hell, JH Mehrkens… - Frontiers in …, 2019 - frontiersin.org
Deep brain stimulation (DBS) has become the treatment of choice for advanced stages of
Parkinson's disease, medically intractable essential tremor, and complicated segmental and …