The Otx2 gene encodes a transcription factor essential for the normal development of brain,
cerebellum, pineal gland, and eye. In the retina, Otx2 has essential functions from early …

Histone H3 lysine 9 trimethylation (H3K9Me3) has been associated with transcriptional
repression, but recent findings implicate this chromatin modification in transcriptional …

Background Dynamic monitoring of protein expression and localization is fundamental to the
understanding of biological processes. The paired-class homeodomain-containing …

The manipulation of neural plasticity as a means of intervening in the onset and progression
of stress-related disorders retains its appeal for many researchers, despite our limited …

Background Many developmental genes are still active in specific tissues after development
is completed. This is the case for the homeobox gene Otx2, an essential actor of forebrain …

The paired-type homeodomain transcription factor Otx2 is essential for forebrain and eye
development. Severe ocular malformations in humans have recently been associated with …

Purpose.: Development of the retinal pigment epithelium (RPE) is controlled by intrinsic and
extrinsic regulators including orthodenticle homeobox 2 (Otx2) and the Wnt/β-catenin …

Mutations in the transcription factors PROP1 and PIT1 (POU1F1) lead to pituitary hormone
deficiency and hypopituitarism in mice and humans. The dysmorphology of developing …

In this study we demonstrated that neural rosettes derived from human ES cells can give rise
either to neural crest precursors, following expansion in presence of bFGF and EGF, or to …

Genetic and embryological experiments demonstrated that the visceral endoderm (VE) is
essential for positioning the primitive streak at one pole of the embryo and head …