Atopic dermatitis (AD) is one of the most prevalent inflammatory disease among non-fatal
skin diseases, affecting up to one fifth of the population in developed countries. AD is …

Epithelial barriers, which include the gastrointestinal, respiratory, and genitourinary mucosa,
compose the body's front line of defense. Since barrier tissues are persistently exposed to …

Antibody-secreting plasma cells (PCs) are generated in secondary lymphoid organs but are
reported to reside in an emerging range of anatomical sites. Analysis of the transcriptome of …

B cell subsets differ in development, tissue distribution, and mechanisms of activation. In
response to infections, however, all can differentiate into extrafollicular plasmablasts that …

B lymphocytes are crucial mediators of systemic immune responses and are known to be
substantial in the pathogenesis of autoimmune diseases with cutaneous manifestations …

Highlights•Specialized plasma cells (PCs) reside in multiple tissues throughout the body.•A
clonally related network of Immunoglobulin (Ig) A PCs occurs at mucosal sites.•Bone marrow …

The skin, covering our entire body as its largest organ, manifests enormous complexities
and a profound interplay of systemic and local responses. In this heterogeneous domain, B …

Mycolactone, a lipid-like toxin, is the major virulence factor of Mycobacterium ulcerans, the
etiological agent of Buruli ulcer. Its involvement in lesion development has been widely …

Tissue-based T cells are important effectors in the prevention and control of mucosal viral
infections; less is known about tissue-based B cells. We demonstrate that B cells and …

Abstract Aims/hypothesis Anorexia Nervosa (AN) is a severe psychiatric disorder of an
unknown etiology with a crude mortality rate of about 5% per decade, making it one of the …