Colorectal cancer (CRC), the third most common type of cancer, is the second leading cause
of cancer-related mortality rates worldwide. Although modern research was able to shed …

Research conducted during the past 30 years has increased our understanding of the
mechanisms involved in colorectal cancer initiation and development. The findings have …

Colorectal cancer arises as a consequence of the accumulation of genetic alterations (gene
mutations, gene amplification, and so on) and epigenetic alterations (aberrant DNA …

Aneuploidy, often preceded by tetraploidy, is one of the hallmarks of solid tumors. Indeed,
both aneuploidy and tetraploidy are oncogenic occurrences that are sufficient to drive …

Chromosome instability, which is equated to mitotic defects and consequential chromosome
segregation errors, provides a formidable basis for the acquisition of further malignant …

The tumor suppressor p53 has long been known to play a central role in maintaining a
stable genome in the face of toxic insults through its role in promoting cell‐cycle …

Although the associations of p53 dysfunction, p53 interaction networks and oncogenesis
have been widely explored, a systematic analysis of TP53 mutations and its related …

Abstract Aurora-A/STK15/BTAK, which encodes a centrosome-associated kinase, is
amplified and overexpressed in multiple types of human tumors, including breast cancer …

It has been four decades since the discovery of p53, the designated 'Guardian of the
Genome'. P53 is primarily known as a master transcription factor and critical tumor …

Multiple myeloma (MM) is the second most common hematological cancer and is
characterized by genetic features including translocations, chromosomal copy number …