Human natural killer cells
MA Caligiuri - Blood, The Journal of the American Society of …, 2008 - ashpublications.org
Natural killer (NK) cells were discovered more than 30 years ago. NK cells are large
granular lymphocytes that belong to the innate immune system because unlike T or B …
granular lymphocytes that belong to the innate immune system because unlike T or B …
KIR: diverse, rapidly evolving receptors of innate and adaptive immunity
C Vilches, P Parham - Annual review of immunology, 2002 - annualreviews.org
KIR genes have evolved in primates to generate a diverse family of receptors with unique
structures that enable them to recognize MHC-class I molecules with locus and allele …
structures that enable them to recognize MHC-class I molecules with locus and allele …
Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G
M Shiroishi, K Tsumoto, K Amano… - Proceedings of the …, 2003 - National Acad Sciences
Ig-like transcript 4 (ILT4)(also known as leukocyte Ig-like receptor 2, CD85d, and LILRB2) is
a cell surface receptor expressed mainly on myelomonocytic cells, whereas ILT2 (also …
a cell surface receptor expressed mainly on myelomonocytic cells, whereas ILT2 (also …
Mouse TIGIT inhibits NK‐cell cytotoxicity upon interaction with PVR
The activity of natural killer (NK) cells is controlled by a balance of signals derived from
inhibitory and activating receptors. TIGIT is a novel inhibitory receptor, recently shown in …
inhibitory and activating receptors. TIGIT is a novel inhibitory receptor, recently shown in …
Immune functions encoded by the natural killer gene complex
WM Yokoyama, BFM Plougastel - Nature Reviews Immunology, 2003 - nature.com
There has been marked progress in our understanding of the role of natural killer (NK) cells
in immune responses, mainly due to the identification of NK-cell receptors and their ligands …
in immune responses, mainly due to the identification of NK-cell receptors and their ligands …
Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect
SS Farag, TA Fehniger, L Ruggeri… - Blood, The Journal …, 2002 - ashpublications.org
Natural killer (NK) cells have held great promise for the immunotherapy of cancer for more
than 3 decades. However, to date only modest clinical success has been achieved …
than 3 decades. However, to date only modest clinical success has been achieved …
Molecular interactions mediating T cell antigen recognition
▪ Abstract Over the past decade, key protein interactions contributing to T cell antigen
recognition have been characterized in molecular detail. These have included interactions …
recognition have been characterized in molecular detail. These have included interactions …
Recognition of peptide–MHC class I complexes by activating killer immunoglobulin-like receptors
CA Stewart, F Laugier-Anfossi, F Vély… - Proceedings of the …, 2005 - National Acad Sciences
Inhibitory receptors for MHC class I molecules increase the threshold of lymphocyte
activation. Natural Killer (NK) cells express a large number of such inhibitory receptors …
activation. Natural Killer (NK) cells express a large number of such inhibitory receptors …
Complex structure of the activating immunoreceptor NKG2D and its MHC class I–like ligand MICA
The major histocompatibility complex (MHC) class I homolog, MICA, is a stress-inducible
ligand for NKG2D, a C-type lectin–like activating immunoreceptor. The crystal structure of …
ligand for NKG2D, a C-type lectin–like activating immunoreceptor. The crystal structure of …
[HTML][HTML] Kinetics and peptide dependency of the binding of the inhibitory NK receptor CD94/NKG2‐A and the activating receptor CD94/NKG2‐C to HLA‐E
M Valés‐Gómez, HT Reyburn, RA Erskine… - The EMBO …, 1999 - embopress.org
The lytic function of human natural killer (NK) cells is markedly influenced by recognition of
class I major histocompatibility complex (MHC) molecules, a process mediated by several …
class I major histocompatibility complex (MHC) molecules, a process mediated by several …