Astrocyte morphology
KT Baldwin, KK Murai, BS Khakh - Trends in cell biology, 2024 - cell.com
Astrocytes are predominant glial cells that tile the central nervous system (CNS). A cardinal
feature of astrocytes is their complex and visually enchanting morphology, referred to as …
feature of astrocytes is their complex and visually enchanting morphology, referred to as …
From compulsivity to compulsion: the neural basis of compulsive disorders
Compulsive behaviour, an apparently irrational perseveration in often maladaptive acts, is a
potential transdiagnostic symptom of several neuropsychiatric disorders, including …
potential transdiagnostic symptom of several neuropsychiatric disorders, including …
Astrocyte Gi-GPCR signaling corrects compulsive-like grooming and anxiety-related behaviors in Sapap3 knockout mice
Astrocytes are morphologically complex cells that serve essential roles. They are widely
implicated in central nervous system (CNS) disorders, with changes in astrocyte morphology …
implicated in central nervous system (CNS) disorders, with changes in astrocyte morphology …
Unraveling the mechanisms of deep-brain stimulation of the internal capsule in a mouse model
BJG van den Boom, A Elhazaz-Fernandez… - Nature …, 2023 - nature.com
Deep-brain stimulation (DBS) is an effective treatment for patients suffering from otherwise
therapy-resistant psychiatric disorders, including obsessive-compulsive disorder …
therapy-resistant psychiatric disorders, including obsessive-compulsive disorder …
Closed-loop recruitment of striatal interneurons prevents compulsive-like grooming behaviors
SL Mondragón-González, C Schreiweis… - Nature …, 2024 - nature.com
Compulsive behaviors have been associated with striatal hyperactivity. Parvalbumin-
positive striatal interneurons (PVIs) in the striatum play a crucial role in regulating striatal …
positive striatal interneurons (PVIs) in the striatum play a crucial role in regulating striatal …
[HTML][HTML] Mechanisms of pathogenesis and environmental moderators in preclinical models of compulsive-like behaviours
Obsessive-compulsive and related disorders (OCRD) is an emergent class of psychiatric
illnesses that contributes substantially to the global mental health disease burden. In …
illnesses that contributes substantially to the global mental health disease burden. In …
Striking long-term beneficial effects of single dose psilocybin and psychedelic mushroom extract in the SAPAP3 rodent model of OCD-like excessive self-grooming
M Brownstien, M Lazar, A Botvinnik, C Shevakh… - Molecular …, 2024 - nature.com
Obsessive compulsive disorder (OCD) is a highly prevalent disorder that causes serious
disability. Available treatments leave 40% or more of people with OCD significantly …
disability. Available treatments leave 40% or more of people with OCD significantly …
The emerging complexity of molecular pathways implicated in mouse self-grooming behavior
AN Ikrin, AM Moskalenko, RR Mukhamadeev… - Progress in Neuro …, 2023 - Elsevier
Rodent self-grooming is an important complex behavior, and its deficits are translationally
relevant to a wide range of neuropsychiatric disorders. Here, we analyzed a comprehensive …
relevant to a wide range of neuropsychiatric disorders. Here, we analyzed a comprehensive …
Hyperactivity of indirect pathway-projecting spiny projection neurons promotes compulsive behavior
SC Piantadosi, EE Manning, BL Chamberlain… - Nature …, 2024 - nature.com
Compulsive behaviors are a hallmark symptom of obsessive compulsive disorder (OCD).
Striatal hyperactivity has been linked to compulsive behavior generation in correlative …
Striatal hyperactivity has been linked to compulsive behavior generation in correlative …
Opening new vistas on obsessive-compulsive disorder with the Observing Response Task
L Pickenhan, AL Milton - Cognitive, Affective, & Behavioral Neuroscience, 2024 - Springer
Abstract Obsessive-compulsive disorder (OCD), a highly prevalent and debilitating disorder,
is incompletely understood in terms of underpinning behavioural, psychological, and neural …
is incompletely understood in terms of underpinning behavioural, psychological, and neural …