The family of VPS10p-Domain (D) receptors comprises five members named SorLA, Sortilin,
SorCS1, SorCS2 and SorCS3. While their physiological roles remain incompletely resolved …

Perturbations of the endolysosomal pathway have been suggested to play an important role
in the pathogenesis of several neurodegenerative diseases, including Parkinson's disease …

Abstract Background Loss of the Sortilin-related receptor 1 (SORL1) gene seems to act as a
causal event for Alzheimer's disease (AD). Recent studies have established that loss of …

A limitation of conventional bulk-tissue proteome studies in amyotrophic lateral sclerosis
(ALS) is the confounding of motor neuron (MN) signals by admixed non-MN proteins. Here …

The established causal genes in Alzheimer's disease (AD), APP, PSEN1, and PSEN2, are
functionally characterized using biomarkers, capturing an in vivo profile reflecting the …

SORL1 is implicated in the pathogenesis of Alzheimer's disease (AD) through genetic
studies. To interrogate the roles of SORL1 in human brain cells, SORL1-null induced …

SORL1, the gene encoding the large multidomain SORLA protein, has emerged as only the
fourth gene that when mutated can by itself cause Alzheimer's disease (AD), and as a gene …

On the causal role of retromer-dependent endosomal recycling in Alzheimer’s disease | Nature
Cell Biology Skip to main content Thank you for visiting nature.com. You are using a browser …

Gene expression is changed by disease, but how these molecular responses arise and
contribute to pathophysiology remains less understood. We discover that β-amyloid, a …

Over the past two decades, increased research has highlighted the connection between
endosomal trafficking defects and neurodegeneration. The endo-lysosomal network is an …