The liver is the only solid organ that uses regenerative mechanisms to ensure that the liver-
to-bodyweight ratio is always at 100% of what is required for body homeostasis. Other solid …

Signals related to liver regeneration (LR) have been identified by triggering proliferation in
hepatocyte cultures, delay of regeneration associated with signal ablation in genomically …

Bile acids are synthesized from cholesterol in the liver. Some cytochrome P450 (CYP)
enzymes play key roles in bile acid synthesis. Bile acids are physiological detergent …

Studies examining the mechanisms by which the liver incurs injury and then regenerates
usually focus on factors and pathways directly within the liver, neglecting the signaling …

The regenerative capability of liver is well known, and the mechanisms that regulate liver
regeneration are extensively studied. Such analyses have defined general principles that …

The prevalence of nonalcoholic fatty liver disease (NAFLD) worldwide has increased at an
alarming rate, which will likely result in enormous medical and economic burden. NAFLD …

The regenerative capacity of the liver is essential for recovery from surgical resection or
injuries induced by trauma or toxins. During liver regeneration, the concentration of …

The nuclear receptor farnesoid X receptor (FXR) is the master regulator of bile acids (BAs)
homeostasis since it transcriptionally drives modulation of BA synthesis, influx, efflux, and …

Hepatocyte nuclear factor 4 alpha (HNF4α) is critical for hepatic differentiation. Recent
studies have highlighted its role in inhibition of hepatocyte proliferation and tumor …

Hepatocyte nuclear factor 4 alpha (HNF4α), the master regulator of hepatocyte
differentiation, has been recently shown to inhibit hepatocyte proliferation by way of …