The role of autophagy in viral infections

T Chen, S Tu, L Ding, M Jin, H Chen, H Zhou - Journal of biomedical …, 2023 - Springer
Autophagy is an evolutionarily conserved catabolic cellular process that exerts antiviral
functions during a viral invasion. However, co-evolution and co-adaptation between viruses …

Autophagy modulation as a potential therapeutic target for diverse diseases

DC Rubinsztein, P Codogno, B Levine - Nature reviews Drug discovery, 2012 - nature.com
Autophagy is an essential, conserved lysosomal degradation pathway that controls the
quality of the cytoplasm by eliminating protein aggregates and damaged organelles. It …

Autophagy in immunity and inflammation

B Levine, N Mizushima, HW Virgin - Nature, 2011 - nature.com
Autophagy is an essential, homeostatic process by which cells break down their own
components. Perhaps the most primordial function of this lysosomal degradation pathway is …

[HTML][HTML] Autophagy and the integrated stress response

G Kroemer, G Mariño, B Levine - Molecular cell, 2010 - cell.com
Autophagy is a tightly regulated pathway involving the lysosomal degradation of cytoplasmic
organelles or cytosolic components. This pathway can be stimulated by multiple forms of …

The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections

P Mehrbod, SR Ande, J Alizadeh, S Rahimizadeh… - Virulence, 2019 - Taylor & Francis
Virus infection induces different cellular responses in infected cells. These include cellular
stress responses like autophagy and unfolded protein response (UPR). Both autophagy and …

[HTML][HTML] Biological functions and regulatory mechanisms of hypoxia-inducible factor-1α in ischemic stroke

Q He, Y Ma, J Liu, D Zhang, J Ren, R Zhao… - Frontiers in …, 2021 - frontiersin.org
Ischemic stroke is caused by insufficient cerebrovascular blood and oxygen supply. It is a
major contributor to death or disability worldwide and has become a heavy societal and …

Inflammation-induced, STING-dependent autophagy restricts Zika virus infection in the Drosophila brain

Y Liu, B Gordesky-Gold, M Leney-Greene… - Cell host & …, 2018 - cell.com
The emerging arthropod-borne flavivirus Zika virus (ZIKV) is associated with neurological
complications. Innate immunity is essential for the control of virus infection, but the innate …

Molecular biology of atherosclerosis

PN Hopkins - Physiological reviews, 2013 - journals.physiology.org
At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Autophagy signal transduction by ATG proteins: from hierarchies to networks

S Wesselborg, B Stork - Cellular and molecular life sciences, 2015 - Springer
Autophagy represents an intracellular degradation process which is involved in both cellular
homeostasis and disease settings. In the last two decades, the molecular machinery …

Host immune responses to Toxoplasma gondii

M Sasai, A Pradipta, M Yamamoto - International Immunology, 2018 - academic.oup.com
Toxoplasma gondii can infect homoeothermic animals including humans and cause lethal
toxoplasmosis in immunocompromised individuals. When hosts are infected with T. gondii …