[HTML][HTML] Adherence, resistance, and viral suppression on dolutegravir in sub-Saharan Africa: implications for the TLD era
SM McCluskey, T Pepperrell, A Hill, WDF Venter… - Aids, 2021 - journals.lww.com
Dolutegravir (DTG) is now a component of preferred first-line antiretroviral therapy (ART)
worldwide. ADVANCE and NAMSAL were two landmark clinical trials conducted exclusively …
worldwide. ADVANCE and NAMSAL were two landmark clinical trials conducted exclusively …
[HTML][HTML] Resistance to HIV integrase inhibitors: about R263K and E157Q mutations
C Charpentier, D Descamps - Viruses, 2018 - mdpi.com
The use of integrase inhibitors (INI) is increasing in antiretroviral therapies (ART) and INI are
not all equal regarding genetic barrier to resistance. The aim of this manuscript was to …
not all equal regarding genetic barrier to resistance. The aim of this manuscript was to …
[HTML][HTML] Selective resistance profiles emerging in patient-derived clinical isolates with cabotegravir, bictegravir, dolutegravir, and elvitegravir
M Oliveira, RI Ibanescu, K Anstett, T Mésplède… - Retrovirology, 2018 - Springer
Background Integrase strand transfer inhibitors (INSTIs) are recommended for first-line HIV
therapy based on their relatively high genetic barrier to resistance. Although raltegravir …
therapy based on their relatively high genetic barrier to resistance. Although raltegravir …
Predictors of virological failure and time to viral suppression of first-line integrase inhibitor–based antiretroviral treatment
A Pyngottu, AU Scherrer, R Kouyos… - Clinical infectious …, 2021 - academic.oup.com
Background Integrase strand transfer inhibitors (InSTIs) are recommended for first-line
treatment of persons with human immunodeficiency virus (HIV). We identified risk factors …
treatment of persons with human immunodeficiency virus (HIV). We identified risk factors …
Prevalence of genotypic baseline risk factors for cabotegravir+ rilpivirine failure among ARV-naive patients
C Charpentier, A Storto, C Soulié… - Journal of …, 2021 - academic.oup.com
Background Multivariable baseline factor analysis across cabotegravir+ rilpivirine clinical
trials showed that HIV-1 subtypes A6/A1 and the presence of rilpivirine resistance …
trials showed that HIV-1 subtypes A6/A1 and the presence of rilpivirine resistance …
Virological outcomes of various first-line ART regimens in patients harbouring HIV-1 E157Q integrase polymorphism: a multicentre retrospective study
S Uno, H Gatanaga, T Hayashida… - Journal of …, 2023 - academic.oup.com
Background Integrase strand transfer inhibitors (INSTIs) are recommended as first-line ART
for people living with HIV (PLWH) in most guidelines. The INSTI-resistance-associated …
for people living with HIV (PLWH) in most guidelines. The INSTI-resistance-associated …
Increased viral load in a hospitalized patient on treatment with crushed bictegravir/emtricitabine/tenofovir alafenamide: a case report and review of the literature
SM Rowe, JC Clary, M Drummond… - American Journal of …, 2022 - academic.oup.com
Purpose To describe a case of increased viral load in a patient with HIV-1 infection receiving
treatment with crushed bictegravir/emtricitabine/tenofovir alafenamide (B/FTC/TAF) …
treatment with crushed bictegravir/emtricitabine/tenofovir alafenamide (B/FTC/TAF) …
Surveillance of transmitted drug resistance to integrase inhibitors in Spain: implications for clinical practice
M Alvarez, P Casas, A de Salazar… - Journal of …, 2019 - academic.oup.com
Background Integrase strand-transfer inhibitors (INSTIs) constitute at present one of the
pillars of first-line ART. Objectives To study the prevalence of and the trend in transmitted …
pillars of first-line ART. Objectives To study the prevalence of and the trend in transmitted …
[HTML][HTML] Dolutegravir Plus Lamivudine Two-Drug Regimen: Safety, Efficacy and Diagnostic Considerations for Its Use in Real-Life Clinical Practice—A Refined …
V Cento, CF Perno - Diagnostics, 2021 - mdpi.com
The diagnostic and therapeutic management of the Coronavirus Disease 2019 (COVID-19)
pandemic in the HIV population brought some known criticalities (and opportunities) to the …
pandemic in the HIV population brought some known criticalities (and opportunities) to the …
Evaluation of virological response and resistance profile in HIV-1 infected patients starting a first-line integrase inhibitor-based regimen in clinical settings
Background Virological response and resistance profile were evaluated in drug-naïve
patients starting their first-line integrase inhibitors (INIs)-based regimen in a clinical setting …
patients starting their first-line integrase inhibitors (INIs)-based regimen in a clinical setting …