The continued threat of emerging flaviviruses
TC Pierson, MS Diamond - Nature microbiology, 2020 - nature.com
Flaviviruses are vector-borne RNA viruses that can emerge unexpectedly in human
populations and cause a spectrum of potentially severe diseases including hepatitis …
populations and cause a spectrum of potentially severe diseases including hepatitis …
Nucleic acid detection using CRISPR/Cas biosensing technologies
For infectious diseases, rapid and accurate identification of the pathogen is critical for
effective management and treatment, but diagnosis remains challenging, particularly in …
effective management and treatment, but diagnosis remains challenging, particularly in …
Zika virus infection enhances future risk of severe dengue disease
LC Katzelnick, C Narvaez, S Arguello… - Science, 2020 - science.org
The Zika pandemic sparked intense interest in whether immune interactions among dengue
virus serotypes 1 to 4 (DENV1 to-4) extend to the closely related Zika virus (ZIKV). We …
virus serotypes 1 to 4 (DENV1 to-4) extend to the closely related Zika virus (ZIKV). We …
Field-deployable viral diagnostics using CRISPR-Cas13
Mitigating global infectious disease requires diagnostic tools that are sensitive, specific, and
rapidly field deployable. In this study, we demonstrate that the Cas13-based SHERLOCK …
rapidly field deployable. In this study, we demonstrate that the Cas13-based SHERLOCK …
Antibody-dependent enhancement of severe dengue disease in humans
LC Katzelnick, L Gresh, ME Halloran, JC Mercado… - Science, 2017 - science.org
For dengue viruses 1 to 4 (DENV1-4), a specific range of antibody titer has been shown to
enhance viral replication in vitro and severe disease in animal models. Although suspected …
enhance viral replication in vitro and severe disease in animal models. Although suspected …
Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region
The clinical outcomes associated with Zika virus (ZIKV) in the Americas have been well
documented, but other aspects of the pandemic, such as attack rates and risk factors, are …
documented, but other aspects of the pandemic, such as attack rates and risk factors, are …
Strategies for developing sensitive and specific nanoparticle-based lateral flow assays as point-of-care diagnostic device
From a home-based pregnancy self-testing kit, lateral flow assays (LFAs) have proliferated
and gained widespread utilization as point-of-care (POC) test kits. Their prevalence is due to …
and gained widespread utilization as point-of-care (POC) test kits. Their prevalence is due to …
Effects of boosting and waning in highly exposed populations on dengue epidemic dynamics
RA Aogo, JV Zambrana, N Sanchez, S Ojeda… - Science translational …, 2023 - science.org
Sequential infection with multiple dengue virus (DENV) serotypes is thought to induce
enduring protection against dengue disease. However, long-term antibody waning has been …
enduring protection against dengue disease. However, long-term antibody waning has been …
High Zika virus seroprevalence in Salvador, northeastern Brazil limits the potential for further outbreaks
During 2015 to 2016, Brazil reported more Zika virus (ZIKV) cases than any other country,
yet population exposure remains unknown. Serological studies of ZIKV are hampered by …
yet population exposure remains unknown. Serological studies of ZIKV are hampered by …
Single-copy sensitive, field-deployable, and simultaneous dual-gene detection of SARS-CoV-2 RNA via modified RT–RPA
Dear Editor, Since the end of 2019, the world is suffering an outbreak of COVID-19
pneumonia caused by SARS-CoV-2 (2019-nCoV) 1 with over 84,000 infections in China …
pneumonia caused by SARS-CoV-2 (2019-nCoV) 1 with over 84,000 infections in China …