In the past two decades, technological advances have brought unprecedented insights into
the paediatric cancer genome revealing characteristics distinct from those of adult cancer …

Synovial sarcoma (SS) is one of the most common types of pediatric soft tissue sarcoma
(STS) being far less frequent in adults. This STS type is characterized by one specific …

Control of stem cell-associated genes by Trithorax group (TrxG) and Polycomb group (PcG)
proteins is frequently misregulated in cancer. In leukemia, oncogenic fusion proteins hijack …

The SS18-SSX fusion protein is an oncogenic driver in synovial sarcoma. At the molecular
level, SS18-SSX functions as both an activator and a repressor to coordinate transcription of …

Survival for children with cancer has primarily improved over the past decades due to
refinements in surgery, radiation and chemotherapy. Although these general therapies are …

Synovial sarcoma is an aggressive soft-tissue malignancy that is characterized by a
pathognomonic t (X; 18)(p11. 2; q11. 2) translocation, which produces the fusion oncogene …

Synovial sarcoma (SyS) is an aggressive soft-tissue malignancy characterized by a
pathognomonic chromosomal translocation leading to the formation of the SS18:: SSX …

Synovial sarcoma (SS) is a rare soft tissue sarcoma characterized by high-grade malignancy
and poor prognosis. Preliminary research indicates that apoptosis evasion is a key factor in …

Simple Summary Fusion proteins are an important class of oncogenes in sarcoma.
Approximately 40 percent of all sarcoma entities are driven by one of the more than 100 …

Synovial Sarcoma (SySa) is an aggressive soft tissue sarcoma that accounts for 5–10% of
all soft tissue sarcomas. Current treatment involves radiation and radical surgery including …