Difluorocarbene is a versatile, reactive intermediate for use in organic synthesis. Over the
past decade, significant progress has been made in difluorocarbene chemistry owing to the …

Within the canonical repertoire of the amino acid involved in protein biogenesis, proline
plays a unique role as an amino acid presenting a modified backbone rather than a side …

Abstract The Ar‐CF2H moiety is featured in an increasing number of bioactive compounds
due to its unique combination of properties. The hydrodefluorination of Ar‐CF3 compounds …

A practical synthetic approach to the difluoro-substituted bicyclo [1.1. 1] pentanes was
developed. The key step was an addition of difluorocarbene (: CF2) to electron-rich bicyclo …

Recent advances in trifluoromethylation or difluoroalkylation reactions by use of
difluorinated phosphonium salts are summarized. In the presence of base, water …

Amide bonds at the proline nitrogen are particularly susceptible to rotation, affording cis and
trans isomers. Installation of a stereochemically defined electron-withdrawing fluorine atom …

In the context of drug discovery, novel spirocyclic pyrrolidines have been synthesized in two
steps from common three‐to seven‐membered‐ring (hetero) alicyclic ketones. The key …

The 2‐substituted piperidine core is found in drugs (18 FDA‐approved drugs), however,
their spirocyclic analogues remain unknown. Described here is the synthesis of spirocyclic …

Fluorinated prolines play an important role in peptide studies, protein engineering,
medicinal chemistry, drug discovery, and agrochemistry. Since the first synthesis of 4 …

BP100 is a multifunctional membrane-active peptide of only 11 amino acids, with a high
antimicrobial activity, an efficient cell-penetrating ability, and low hemolytic side-effects. It …