Mass spectrometry imaging (MSI) is a powerful tool that enables untargeted investigations
into the spatial distribution of molecular species in a variety of samples. It has the capability …

The early 2000s brought a new age in the field of mass spectrometry (MS) with the
introduction of ambient ionization MS techniques. As defined by one of its early visionaries …

Spatial metabolomics is an emerging field of omics research that has enabled localizing
small molecules in tissues and cells. Mass spectrometry imaging (MSI) technologies allow …

Metabolomics has grown into a prominent field contributing to the molecular understanding
of complex biological processes in both health and disease. Furthermore, single-cells are …

Owing to recent advances in mass spectrometry (MS), tens to hundreds of proteins, lipids,
and small molecules can be measured in single cells. The ability to characterize the …

Compositional diversity is a fundamental property in cell populations. Single‐cell analysis
promises new insight into this cellular heterogeneity on the genomic, transcriptomic …

Advances of analytical methods and emerging microfluidic tools have made it possible to
investigate biological processes in living organisms in detail and reach sensitivities sufficient …

Mass spectrometry imaging (MSI) techniques make possible the spatial chemical
identification of analytes, especially for biological samples. As a universal energy source …

Heterogeneity in cell populations is a phenomenon encountered in virtually all biological
systems, in whole tissues and cell cultures and from bacterial to mammalian cells. Moreover …

Molecular profiling of single cells has the potential to significantly advance our
understanding of cell function and cellular processes of importance to health and disease. In …