Protein lipidation is a common post-translational modification of proteins that plays an
important role in human physiology and pathology. One form of protein lipidation, S …

2-Bromohexadecanoic acid, or 2-bromopalmitate, was introduced nearly 50 years ago as a
nonselective inhibitor of lipid metabolism. More recently, 2-bromopalmitate re-emerged as a …

Protein palmitoylation describes the post-translational fatty acyl thioesterification of cellular
cysteine residues and is critical for the localization, trafficking, and compartmentalization of a …

Pharmacologic approaches to studying palmitoylation are limited by the lack of specific
inhibitors. Recently, screens have revealed five chemical classes of small molecules that …

Extracellular vesicles (EVs) are membrane-enclosed particles that play an important role in
cancer progression and have emerged as a promising source of circulating biomarkers …

Coronaviruses are enveloped RNA viruses that generally cause mild disease in humans.
However, the recently emerged coronavirus that caused severe acute respiratory syndrome …

Protein palmitoylation is the post-translational addition of the 16-carbon fatty acid palmitate
to specific cysteine residues by a labile thioester linkage. Palmitoylation is mediated by a …

Heterotrimeric G proteins (αβγ) mediate the majority of signaling pathways in mammalian
cells. It is long held that G protein function is localized to the plasma membrane. Here we …

The mechanistic target of rapamycin (mTOR) Complex 1 (mTORC1) controls growth and
proliferation of non-neuronal cells, while during neuronal development mTORC1 responds …

Palmitoylation, a lipid-based posttranslational protein modification, plays a crucial role in
regulating various aspects of neuronal function through altering protein membrane …