The aim of docking is to accurately predict the structure of a ligand within the constraints of a
receptor binding site and to correctly estimate the strength of binding. We discuss, in detail …

Ureases are enzymes that hydrolyze urea into ammonium and carbon dioxide. They have
received considerable attention due to their impacts on living organism health, since the …

Hybrid analogs containing molecules are always the choice of different synthetic researcher
due to their diverse biological applications and significantly more efficient. Heterocyclic …

This research work represents a synthetic approach for the development of hybrids
derivatives of oxadiazole-based benzothiazole (1–17) and diversity in derivatives was …

Two new water-soluble thiadiazole compounds are prepared and characterized with various
techniques. These compounds, 5-amino-1, 3, 4-thiadiazole hydrochloride (1) and 5-amino-3 …

Twenty-four analogs based on triazinoindole bearing benzimidazole/benzoxazole moieties
(1–25) were synthesized. Utilizing a variety of spectroscopic methods, including 1H-, 13C …

Combating several pathological conditions associated with ureolytic enzyme (urease)
remains a formidable challenge because of the lack of effective and safe drug therapies. In …

Ureases have emerged as significant virulence factors implicated in the pathogenesis of
many clinical conditions such as pyelonephritis, hepatic coma, peptic ulceration, and the …

The discovery of life-changing medicines continues to be the driving force for the rapid
exploration and expansion of chemical space, enabling access to innovative small …

Syringaldehyde is a promising aromatic aldehyde that no longer deserves to remain in
obscurity. It possesses worthy bioactive properties and is, therefore, used in …