Astrocytes as a therapeutic target in alzheimer's disease–comprehensive review and recent developments

M Rodríguez-Giraldo, RE González-Reyes… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is a frequent and disabling neurodegenerative disorder, in which
astrocytes participate in several pathophysiological processes including neuroinflammation …

Exploring ER stress response in cellular aging and neuroinflammation in Alzheimer's disease

MS Uddin, WS Yu, LW Lim - Ageing Research Reviews, 2021 - Elsevier
One evident hallmark of Alzheimer's disease (AD) is the irregular accumulation of proteins
due to changes in proteostasis involving endoplasmic reticulum (ER) stress. To alleviate ER …

Double stochastic resonance in neuronal dynamics due to astrocytes

T Palabas, JJ Torres, M Perc, M Uzuntarla - Chaos, Solitons & Fractals, 2023 - Elsevier
A continuously growing body of evidence indicates that astrocytes, which is the most
abundant sub-type of glial cells in the nervous system, not only provide structural and …

Multi-target drug candidates for multifactorial Alzheimer's disease: AChE and NMDAR as molecular targets

MS Uddin, A Al Mamun, MT Kabir, GM Ashraf… - Molecular …, 2021 - Springer
Alzheimer's disease (AD) is one of the most common forms of dementia among elder
people, which is a progressive neurodegenerative disease that results from a chronic loss of …

Role of environmental pollutants in Alzheimer's disease: a review

RH Mir, G Sawhney, FH Pottoo, R Mohi-Ud-Din… - … Science and Pollution …, 2020 - Springer
Neurodegenerative disorders are commonly erratic influenced by various factors including
lifestyle, environmental, and genetic factors. In recent observations, it has been …

Revisiting the amyloid cascade hypothesis: from anti-Aβ therapeutics to auspicious new ways for Alzheimer's disease

MS Uddin, MT Kabir, MS Rahman, T Behl… - International journal of …, 2020 - mdpi.com
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder related to age,
characterized by the cerebral deposition of fibrils, which are made from the amyloid-β (Aβ), a …

Natural Anti-inflammatory compounds as Drug candidates in Alzheimer's disease

RH Mir, AJ Shah, R Mohi-Ud-Din… - Current medicinal …, 2021 - ingentaconnect.com
Alzheimer's disease (AD) is a chronic neurodegenerative brain disorder characterized by
memory impairment, dementia, and oxidative stress in elderly people. Currently, only a few …

[HTML][HTML] Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease

SN Austad, S Ballinger, TW Buford, CS Carter… - … Pharmaceutica Sinica B, 2022 - Elsevier
Aging is by far the most prominent risk factor for Alzheimer's disease (AD), and both aging
and AD are associated with apparent metabolic alterations. As developing effective …

[HTML][HTML] Neuroinflammatory signaling in the pathogenesis of Alzheimer's disease

MS Uddin, MT Kabir, M Jalouli… - Current …, 2022 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the
formation of intracellular neurofibrillary tangles (NFTs) and extracellular amyloid plaques …

Structural characterization of polysaccharide purified from Amanita caesarea and its pharmacological basis for application in Alzheimer's disease: endoplasmic …

W Hu, Z Li, W Wang, M Song, R Dong, Y Zhou, Y Li… - Food & Function, 2021 - pubs.rsc.org
Alzheimer's disease (AD) leads to progressive declines in memory and learning. This
disease may arise from endoplasmic reticulum stress due to protein misfolding, which …