Degradation of mitochondria via a selective form of autophagy, named mitophagy, is a
fundamental mechanism conserved from yeast to humans that regulates mitochondrial …

Mitophagy is a selective autophagic process, essential for cellular homeostasis, that
eliminates dysfunctional mitochondria. Activated by inner membrane depolarization, it plays …

It is unknown what occurs if both mitochondrial division and fusion are completely blocked.
Here, we introduced mitochondrial stasis by deleting two dynamin-related GTPases for …

Objective Metabolomic studies suggest plasma levels of bile acids (BAs) are elevated
amongst subjects with non-alcoholic fatty liver disease (NAFLD) compared to healthy …

Abstract Background and Aims The prevalence of nonalcoholic fatty liver disease (NAFLD)
and steatohepatitis (NASH) is increasing at an alarming rate. The role of bile acids in the …

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
worldwide, with a prevalence of 25–30%. Since its first description in 1980, NAFLD has …

Background: Obesity is often associated with nonalcoholic fatty liver disease (NAFLD),
which refers to a large spectrum of hepatic lesions including fatty liver, nonalcoholic …

The development of nonalcoholic fatty liver disease (NAFLD) is associated with increased
reactive oxygen species (ROS) production. Previous observations on the contradictory roles …

Background: The quantitative, measurable detection of drinking is important for the
successful treatment of alcohol misuse in transplantation of patients with alcohol disorders …

The spectrum of alcoholic liver disease (ALD) is broad and includes alcoholic fatty liver,
alcoholic steatohepatitis, alcoholic hepatitis, alcoholic fibrosis, alcoholic cirrhosis, and …