Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Notch signaling is involved in cell fate determination and deregulated in human solid
tumors. Hypoxia is an important feature in many solid tumors, which activates hypoxia …

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death globally. The
cancer stem cells (CSCs) of HCC are responsible for tumor growth, invasion, metastasis …

The Notch pathway represents a highly conserved signaling network with essential roles in
regulation of key cellular processes and functions, many of which are critical for …

Hepatocellular carcinoma (HCC) is the most common liver cancer, accounting for 90% of
primary liver cancers. In the last decade it has become one of the most frequently occurring …

The Notch signaling pathway, known to be a highly conserved signaling pathway in
embryonic development and adult tissue homeostasis, participates in cell fate decisions that …

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality
worldwide. Sorafenib is the first multi-tyrosine kinase inhibitor approved for HCC and it has …

The cancer stem cell (CSC) hypothesis was first proposed over 40 years ago. Advances in
CSC isolation were first achieved in hematological malignancies, with the first CSC …

A characteristic shared by most frequent types of primary liver cancer, ie, hepatocellular
carcinoma (HCC) and cholangiocarcinoma (CCA) in adults, and in a lesser extent …

The Notch family is a highly conserved gene group that regulates cell‐cell interaction,
embryogenesis, and tissue commitment. This review article focuses on the third Notch family …