Writing, erasing and reading histone lysine methylations
Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …
many cellular events. Lysine methylations mark various sites on the tail and globular …
The diverse functions of Dot1 and H3K79 methylation
DOT1 (disruptor of telomeric silencing; also called Kmt4) was initially discovered in budding
yeast in a genetic screen for genes whose deletion confers defects in telomeric silencing …
yeast in a genetic screen for genes whose deletion confers defects in telomeric silencing …
DOT1L and H3K79 methylation in transcription and genomic stability
The organization of eukaryotic genomes into chromatin provides challenges for the cell to
accomplish basic cellular functions, such as transcription, DNA replication and repair of DNA …
accomplish basic cellular functions, such as transcription, DNA replication and repair of DNA …
The many faces of histone H3K79 methylation
Abstract Dot1/DOT1L (disruptor of telomeric silencing-1) is an evolutionarily conserved
histone methyltransferase that methylates lysine 79 located within the globular domain of …
histone methyltransferase that methylates lysine 79 located within the globular domain of …
The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle
W Kim, M Choi, JE Kim - Cell Cycle, 2014 - Taylor & Francis
Dot1/DOT1L catalyzes the methylation of histone H3 lysine 79 (H3K79), which regulates
diverse cellular processes, such as development, reprogramming, differentiation, and …
diverse cellular processes, such as development, reprogramming, differentiation, and …
Processing of DNA polymerase-blocking lesions during genome replication is spatially and temporally segregated from replication forks
RP Wong, N García-Rodríguez, N Zilio, M Hanulová… - Molecular cell, 2020 - cell.com
Tracing DNA repair factors by fluorescence microscopy provides valuable information about
how DNA damage processing is orchestrated within cells. Most repair pathways involve …
how DNA damage processing is orchestrated within cells. Most repair pathways involve …
Dot1-dependent histone H3K79 methylation promotes activation of the Mek1 meiotic checkpoint effector kinase by regulating the Hop1 adaptor
During meiosis, accurate chromosome segregation relies on the proper interaction between
homologous chromosomes, including synapsis and recombination. The meiotic …
homologous chromosomes, including synapsis and recombination. The meiotic …
Biological function and regulation of histone and non-histone lysine methylation in response to DNA damage
DNA damage response (DDR) signaling network is initiated to protect cells from various
exogenous and endogenous damage resources. Timely and accurate regulation of DDR …
exogenous and endogenous damage resources. Timely and accurate regulation of DDR …
Reversal of PCNA Ubiquitylation by Ubp10 in Saccharomyces cerevisiae
A Gallego-Sánchez, S Andrés, F Conde… - PLoS …, 2012 - journals.plos.org
Regulation of PCNA ubiquitylation plays a key role in the tolerance to DNA damage in
eukaryotes. Although the evolutionary conserved mechanism of PCNA ubiquitylation is well …
eukaryotes. Although the evolutionary conserved mechanism of PCNA ubiquitylation is well …
Helicase subunit Cdc45 targets the checkpoint kinase Rad53 to both replication initiation and elongation complexes after fork stalling
G Can, AC Kauerhof, D Macak, P Zegerman - Molecular cell, 2019 - cell.com
Across eukaryotes, disruption of DNA replication causes an S phase checkpoint response,
which regulates multiple processes, including inhibition of replication initiation and fork …
which regulates multiple processes, including inhibition of replication initiation and fork …