DNA double-strand break repair-pathway choice in somatic mammalian cells
The major pathways of DNA double-strand break (DSB) repair are crucial for maintaining
genomic stability. However, if deployed in an inappropriate cellular context, these same …
genomic stability. However, if deployed in an inappropriate cellular context, these same …
Breaking the chains: deubiquitylating enzyme specificity begets function
The deubiquitylating enzymes (DUBs, also known as deubiquitylases or deubiquitinases)
maintain the dynamic state of the cellular ubiquitome by releasing conjugated ubiquitin from …
maintain the dynamic state of the cellular ubiquitome by releasing conjugated ubiquitin from …
[HTML][HTML] Methods favoring homology-directed repair choice in response to CRISPR/Cas9 induced-double strand breaks
H Yang, S Ren, S Yu, H Pan, T Li, S Ge… - International journal of …, 2020 - mdpi.com
Precise gene editing is—or will soon be—in clinical use for several diseases, and more
applications are under development. The programmable nuclease Cas9, directed by a …
applications are under development. The programmable nuclease Cas9, directed by a …
The complementarity of DDR, nucleic acids and anti-tumour immunity
Immune checkpoint blockade (ICB) immunotherapy is a first-line treatment for selected
cancers, yet the mechanisms of its efficacy remain incompletely understood. Furthermore …
cancers, yet the mechanisms of its efficacy remain incompletely understood. Furthermore …
[HTML][HTML] PARP inhibitor resistance: a tug-of-war in BRCA-mutated cells
SM Noordermeer, H van Attikum - Trends in cell biology, 2019 - cell.com
Poly-(ADP)-ribose polymerase (PARP) inhibition is synthetic lethal with deficiency for
homologous recombination (HR), a pathway essential for DNA double-strand break repair …
homologous recombination (HR), a pathway essential for DNA double-strand break repair …
The antitumorigenic roles of BRCA1–BARD1 in DNA repair and replication
M Tarsounas, P Sung - Nature Reviews Molecular Cell Biology, 2020 - nature.com
The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA
double-strand break (DSB) repair by homologous recombination and protects DNA …
double-strand break (DSB) repair by homologous recombination and protects DNA …
The control of DNA repair by the cell cycle
N Hustedt, D Durocher - Nature cell biology, 2017 - nature.com
The correct duplication and transmission of genetic material to daughter cells is the primary
objective of the cell division cycle. DNA replication and chromosome segregation present …
objective of the cell division cycle. DNA replication and chromosome segregation present …
Mechanisms of BRCA1–BARD1 nucleosome recognition and ubiquitylation
Q Hu, MV Botuyan, D Zhao, G Cui, E Mer, G Mer - Nature, 2021 - nature.com
The BRCA1–BARD1 tumour suppressor is an E3 ubiquitin ligase necessary for the repair of
DNA double-strand breaks by homologous recombination,,,,,,,,–. The BRCA1–BARD1 …
DNA double-strand breaks by homologous recombination,,,,,,,,–. The BRCA1–BARD1 …
[HTML][HTML] Histone ubiquitination: an integrative signaling platform in genome stability
F Mattiroli, L Penengo - Trends in Genetics, 2021 - cell.com
Complex mechanisms are in place to maintain genome stability. Ubiquitination of chromatin
plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) …
plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) …
[HTML][HTML] Human Rad52 promotes XPG-mediated R-loop processing to initiate transcription-associated homologous recombination repair
T Yasuhara, R Kato, Y Hagiwara, B Shiotani… - Cell, 2018 - cell.com
Given that genomic DNA exerts its function by being transcribed, it is critical for the
maintenance of homeostasis that DNA damage, such as double-strand breaks (DSBs) …
maintenance of homeostasis that DNA damage, such as double-strand breaks (DSBs) …