Approximately 6% of adults worldwide have atherosclerosis and thrombosis of the lower
limb arteries (peripheral artery disease (PAD)) and the prevalence is rising. PAD causes leg …

Peripheral artery disease (PAD) is a prevalent condition that confers substantial morbidity
and mortality and remains underdiagnosed as well as undertreated in the overall …

Background Patients with chronic limb-threatening ischemia (CLTI) require revascularization
to improve limb perfusion and thereby limit the risk of amputation. It is uncertain whether an …

Patients with widespread atherosclerosis such as peripheral artery disease (PAD) have a
high risk of cardiovascular and limb symptoms and complications, which affects their quality …

Peripheral arterial disease is a chronic vascular disease characterized by impaired
circulation to the lower extremities. Its most severe stage, known as critical limb ischemia …

Restoration of sufficient blood supply for the treatment of ischemia remains a significant
scientific and clinical challenge. Here, a cell‐like nanoparticle delivery technology is …

Peripheral artery disease (PAD) leads to considerable morbidity, yet strategies for
therapeutic angiogenesis fall short of being impactful. Inflammatory macrophage subsets …

Key Clinical Points Chronic Limb-Threatening Ischemia Chronic limb-threatening ischemia
typically manifests as ischemic pain in the distal leg or foot while the patient is at rest, as …

Peripheral artery disease (PAD) poses a great challenge to society, with a growing
prevalence in the upcoming years. Patients in the severe stages of PAD are prone to …

Peripheral artery disease (PAD) is an atherosclerotic disease that impairs blood flow and
muscle function in the lower limbs. A skeletal muscle myopathy characterized by …