Molecular mechanisms of biological aging in intervertebral discs

NV Vo, RA Hartman, PR Patil… - Journal of …, 2016 - Wiley Online Library
Advanced age is the greatest risk factor for the majority of human ailments, including spine‐
related chronic disability and back pain, which stem from age‐associated intervertebral disc …

Ligamentum flavum fibrosis and hypertrophy: molecular pathways, cellular mechanisms, and future directions

C Sun, H Zhang, X Wang, X Liu - The FASEB Journal, 2020 - Wiley Online Library
Hypertrophy of ligamentum flavum (LF), along with disk protrusion and facet joints
degeneration, is associated with the development of lumbar spinal canal stenosis (LSCS) …

Gut-spine axis: a possible correlation between gut microbiota and spinal degenerative diseases

T Morimoto, T Kobayashi, T Kakiuchi, M Esaki… - Frontiers in …, 2023 - frontiersin.org
As society ages, the number of patients with spinal degenerative diseases (SDD) is
increasing, posing a major socioeconomic problem for patients and their families. SDD …

Factors associated with the thickness of the ligamentum flavum: is ligamentum flavum thickening due to hypertrophy or buckling?

N Altinkaya, T Yildirim, S Demir, O Alkan, FB Sarica - Spine, 2011 - journals.lww.com
Study Design. Ligamentum flavum (LF) thickness was measured by using lumbar magnetic
resonance imaging in patients with low back or leg pain. Objective. This study investigated …

Molecular mechanisms of intervertebral disc degeneration

SM Rider, S Mizuno, JD Kang - Spine surgery and related research, 2019 - jstage.jst.go.jp
Intervertebral disc degeneration is a well-known cause of disability, the result of which
includes neck and back pain with associated mobility limitations. The purpose of this article …

[HTML][HTML] Analysis of the relationship between ligamentum flavum thickening and lumbar segmental instability, disc degeneration, and facet joint osteoarthritis in lumbar …

T Yoshiiwa, M Miyazaki, N Notani, T Ishihara… - Asian spine …, 2016 - ncbi.nlm.nih.gov
Analysis of the Relationship between Ligamentum Flavum Thickening and Lumbar
Segmental Instability, Disc Degeneration, and Facet Joint Osteoarthritis in Lumbar Spinal …

Decorin: a potential therapeutic candidate for ligamentum flavum hypertrophy by antagonizing TGF-β1

S Wang, Y Qu, X Fang, Q Ding, H Zhao, X Yu… - … & Molecular Medicine, 2023 - nature.com
Ligamentum flavum hypertrophy (LFH) is the main physiological and pathological
mechanism of lumbar spinal canal stenosis (LSCS). The specific mechanism for LFH has not …

Hypertrophy of ligamentum flavum in lumbar spine stenosis associated with the increased expression of connective tissue growth factor

ZM Zhong, DS Zha, WD Xiao, SH Wu… - Journal of …, 2011 - Wiley Online Library
Hypertrophy of the ligamentum flavum (LF) contributes to lumbar spinal stenosis (LSS), and
results mainly from fibrosis. Connective tissue growth factor (CTGF) is a profibrotic factor …

Body mass index and risk for clinical lumbar spinal stenosis: a cohort study

B Knutsson, B Sandén, G Sjödén, B Järvholm… - Spine, 2015 - journals.lww.com
Study Design. A prospective cohort study that used a Swedish nationwide occupational
surveillance program for construction workers (period of registration from 1971 to 1992). In …

Visually assessed severity of lumbar spinal canal stenosis is paradoxically associated with leg pain and objective walking ability

P Kuittinen, P Sipola, T Saari, TJ Aalto… - BMC musculoskeletal …, 2014 - Springer
Background Lumbar spinal stenosis (LSS) is the common term used to describe patients
with symptoms related to the anatomical reduction of the lumbar spinal canal size. However …