Resistance to cancer therapy is a major barrier to cancer management. Conventional views
have proposed that acquisition of resistance may result from genetic mutations. However …

Highlights•Characteristics of the tumor microenvironment that have to be considered for the
development of 3D cell spheroid model systems for translational cancer research.•Methods …

Increasing studies have demonstrated that most tumors consisted a subpopulation of cells
with stem cell properties, known as cancer stem cells (CSCs). Accumulating evidence …

Medulloblastoma (MB) is the most common childhood malignant brain tumor, accounting for
approximately 20% of all pediatric central nervous system tumors. Current standard …

Breast cancer stem (-like) cells (BCSCs) have been found to be responsible for therapeutic
resistance and disease relapse. BCSCs are difficult to eradicate due to their high resistance …

This work aims at elucidating the mechanism and kinetics of hydrolysis of GANT61, the first
and most-widely used inhibitor of the Hedgehog (Hh) signalling pathway that targets Glioma …

Steroidal alkaloids contain both steroidal and alkaloid properties in terms of chemical
properties and pharmacological activities. Due to outstanding biological activities such as …

Notch signaling is considered a rational target in the therapy of several cancers, particularly
those harbouring Notch gain of function mutations, including T-cell acute lymphoblastic …

Aberrant activation of the Hedgehog (Hh) pathway is responsible for the onset and
progression of several malignancies. Small molecules able to block the pathway at the …

Abstract The Hedgehog (Hh) signaling pathway is a widely appreciated target for anticancer
therapy. However, drug resistance at the Smoothened receptor (SMO) and Hh activation …