Carbonyl stress in red blood cells and hemoglobin
OV Kosmachevskaya, NN Novikova, AF Topunov - Antioxidants, 2021 - mdpi.com
The paper overviews the peculiarities of carbonyl stress in nucleus-free mammal red blood
cells (RBCs). Some functional features of RBCs make them exceptionally susceptible to …
cells (RBCs). Some functional features of RBCs make them exceptionally susceptible to …
Human Triosephosphate Isomerase Is a Potential Target in Cancer Due to Commonly Occurring Post-Translational Modifications
S Enríquez-Flores, I De la Mora-De la Mora… - Molecules, 2023 - mdpi.com
Cancer involves a series of diseases where cellular growth is not controlled. Cancer is a
leading cause of death worldwide, and the burden of cancer incidence and mortality is …
leading cause of death worldwide, and the burden of cancer incidence and mortality is …
[HTML][HTML] Disulfiram as a novel inactivator of Giardia lamblia triosephosphate isomerase with antigiardial potential
A Castillo-Villanueva, Y Rufino-González… - International Journal for …, 2017 - Elsevier
Giardiasis, the infestation of the intestinal tract by Giardia lamblia, is one of the most
prevalent parasitosis worldwide. Even though effective therapies exist for it, the problems …
prevalent parasitosis worldwide. Even though effective therapies exist for it, the problems …
Determining the molecular mechanism of inactivation by chemical modification of triosephosphate isomerase from the human parasite Giardia lamblia: A study for …
S Enríquez‐Flores… - Proteins: Structure …, 2011 - Wiley Online Library
Giardiasis, the most prevalent intestinal parasitosis in humans, is caused by Giardia lamblia.
Current drug therapies have adverse effects on the host, and resistant strains against these …
Current drug therapies have adverse effects on the host, and resistant strains against these …
Proton pump inhibitors drastically modify triosephosphate isomerase from Giardia lamblia at functional and structural levels, providing molecular leads in the design of …
I García-Torres, J Marcial-Quino… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Abstract Background Proton pump inhibitors (PPIs) are extensively used in clinical practice
because of their effectiveness and safety. Omeprazole is one of the best-selling drugs …
because of their effectiveness and safety. Omeprazole is one of the best-selling drugs …
Naturally occurring deamidated triosephosphate isomerase is a promising target for cell-selective therapy in cancer
S Enríquez-Flores, LA Flores-López… - Scientific Reports, 2022 - nature.com
Human triosephosphate isomerase (HsTIM) is a central glycolytic enzyme and is
overexpressed in cancer cells with accelerated glycolysis. Triple-negative breast cancer is …
overexpressed in cancer cells with accelerated glycolysis. Triple-negative breast cancer is …
A guide to the effects of a large portion of the residues of triosephosphate isomerase on catalysis, stability, druggability, and human disease
V Olivares‐Illana, H Riveros‐Rosas… - Proteins: Structure …, 2017 - Wiley Online Library
Triosephosphate isomerase (TIM) is a ubiquitous enzyme, which appeared early in
evolution. TIM is responsible for obtaining net ATP from glycolysis and producing an extra …
evolution. TIM is responsible for obtaining net ATP from glycolysis and producing an extra …
Structural Basis for Redox Regulation of Cytoplasmic and Chloroplastic Triosephosphate Isomerases from Arabidopsis thaliana
LM López-Castillo, P Jiménez-Sandoval… - Frontiers in plant …, 2016 - frontiersin.org
In plants triosephosphate isomerase (TPI) interconverts glyceraldehyde 3-phosphate (G3P)
and dihydroxyacetone phosphate (DHAP) during glycolysis, gluconeogenesis, and the …
and dihydroxyacetone phosphate (DHAP) during glycolysis, gluconeogenesis, and the …
First characterization of a microsporidial triosephosphate isomerase and the biochemical mechanisms of its inactivation to propose a new druggable target
I García-Torres, I De la Mora-De la Mora… - Scientific Reports, 2018 - nature.com
The microsporidia are a large group of intracellular parasites with a broad range of hosts,
including humans. Encephalitozoon intestinalis is the second microsporidia species most …
including humans. Encephalitozoon intestinalis is the second microsporidia species most …
Is Your Kid Actin Out? A Series of Six Patients With Inherited Actin-Related Protein 2/3 Complex Subunit 1B Deficiency and Review of the Literature
E Vásquez-Echeverri… - The Journal of Allergy …, 2023 - Elsevier
Background Hereditary actin-related protein 2/3 complex subunit 1B deficiency is
characterized clinically by ear, skin, and lung infections, bleeding, eczema, food allergy …
characterized clinically by ear, skin, and lung infections, bleeding, eczema, food allergy …