Cell proliferation, apoptosis, autophagy, oxidative stress and metabolic dysregulation are
the basis of many diseases. Forkhead box transcription factor O1 (FOXO1) changes in …

FOXO transcription factors are negatively regulated by the PI3K-PKB/AKT signaling pathway
and have been mainly considered to be tumor suppressors due to their inhibitory effect on …

FoxO1 is a conserved transcription factor involved in energy metabolism. It is tightly
regulated by modifications on its mRNA and protein and responds to environmental nutrient …

Environmental factors (eg, malnutrition and physical inactivity) contribute largely to
metabolic disorders including obesity, type 2 diabetes, cardiometabolic disease and …

Forkhead box-O1 (FOXO1) is a downstream target of AKT and plays crucial roles in cell
cycle control, apoptosis, metabolism and adipocyte differentiation. It is thought that FOXO1 …

Glucose production and the consumption of high levels of carbohydrate increase the chance
of insulin resistance, especially in cases of obesity. Therefore, maintaining a balanced …

Intramuscular fat content is closely related to the quality of beef, where the forkhead box
protein O1 (FOXO1) is involved in adipocyte differentiation and lipid metabolism, but the …

Forkhead box O (FoxO) proteins are transcription factors that mediate many aspects of
physiology and thus have been targeted as therapeutics for several diseases including …

Diffuse midline gliomas (DMGs) including diffuse intrinsic pontine gliomas (DIPGs) bearing
lysine-to-methionine mutations in histone H3 at lysine 27 (H3K27M) are lethal childhood …

Approximately one third of cancer patients die due to complexities related to cachexia.
However, the mechanisms of cachexia and the potential therapeutic interventions remain …