Colorectal cancer (CRC) is one the greatest contributors to cancer related mortality.
Although 5 year survival rate for patients at the early stage of CRC (stages I and II) is above …

Abstract Although 5‑fluorouracil (5‑FU)‑based chemotherapy is the major treatment for
colorectal cancer, it has disadvantages such as systemic toxicity, lack of effectiveness and …

Background The optimum duration of first-line treatment with chemotherapy in combination
with bevacizumab in patients with metastatic colorectal cancer is unknown. The CAIRO3 …

Acclaimed by the worldwide medical community as" a staple reference text in the medical
oncologist's library"(JAMA), DeVita, Hellman, and Rosenberg's Cancer: Principles and …

Background We evaluated capecitabine (an oral fluoropyrimidine) and oxaliplatin (a
platinum compound) as alternatives to infused fluorouracil and cisplatin, respectively, for …

BACKGROUND:: Fluorouracil (FU) is an antimetabolite with activity against numerous types
of neoplasms, including those of the breast, esophagus, larynx, and gastrointestinal and …

Simple Summary The present article reviews the state of the art of metronomic
chemotherapy use to treat the principal types of cancers, namely breast, non-small cell lung …

PURPOSE: Capecitabine is a novel, oral, selectively tumor-activated fluoropyrimidine
carbamate. This large multicenter phase II trial tested the efficacy and safety of twice-daily …

Abstract Purpose: Capecitabine (Xeloda) is a novel fluoropyrimidine carbamate rationally
designed to generate 5-fluorouracil (5-FU) preferentially in tumors. The purpose of this study …

Abstract Learning Objectives After completing this course, the reader will be able to: Define
the main oral prodrugs of fluorouracil. Know the indications of the new oral prodrugs of …