Next-Generation Leishmanization: Revisiting Molecular Targets for Selecting Genetically Engineered Live-Attenuated Leishmania

POL Moreira, PM Nogueira, RL Monte-Neto - Microorganisms, 2023 - mdpi.com
Despite decades of research devoted to finding a vaccine against leishmaniasis, we are still
lacking a safe and effective vaccine for humans. Given this scenario, the search for a new …

The Functional Roles of the Src Homology 2 Domain-Containing Inositol 5-Phosphatases SHIP1 and SHIP2 in the Pathogenesis of Human Diseases

SM Müller, M Jücker - International Journal of Molecular Sciences, 2024 - mdpi.com
The src homology 2 domain-containing inositol 5-phosphatases SHIP1 and SHIP2 are two
proteins involved in intracellular signaling pathways and have been linked to the …

The endoplasmic reticulum of trypanosomatids: An unrevealed road for chemotherapy

JM Sandes, RCBQ de Figueiredo - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
The endoplasmic reticulum (ER) of higher eukaryotic cells forms an intricate membranous
network that serves as the main processing facility for folding and assembling of secreted …