Despite much recent progress, prostate cancer continues to represent a major cause of
cancer-related mortality and morbidity in men. Since early studies on the role of the …

Prostate cancer (PCa) is a prevalent malignancy that occurs primarily in old males. Prostate
tumors in different patients manifest significant inter-patient heterogeneity with respect to …

Autoimmune (AI) diseases can affect many organs; however, the prostate has not been
considered to be a primary target of these systemic inflammatory processes. Here, we utilize …

Animal models, particularly mouse models, play a central role in the study of the etiology,
prevention, and treatment of human prostate cancer. While tissue culture models are …

Carcinoma-associated fibroblasts (CAF) play a critical role in malignant progression. Loss of
TGF-β receptor II (TGFβR2) in the prostate stroma is correlated with prostatic tumorigenesis …

Microscale cell-based assays have demonstrated unique capabilities in reproducing
important cellular behaviors for diagnostics and basic biological research. As these assays …

As a lipoxygenase (LOX), arachidonate 15-lipoxygenase type B (ALOX15B) peroxidizes
polyenoic fatty acids (PUFAs) including arachidonic acid (AA), eicosapentaenoic acid (EPA) …

Trichomonas vaginalis, the etiologic agent of the most common non-viral sexually
transmitted infection worldwide. With an estimated annual prevalence of 276 million new …

BACKGROUND Benign prostatic hyperplasia (BPH) is a common, chronic progressive
disease. Inflammation is associated with prostatic enlargement and resistance to 5α …

Blocking androgen receptor signaling is the mainstay of therapy for advanced prostate
cancer (PCa). However, acquired resistance to single agents targeting this pathway results …