Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 38-amino acid C-terminally
α-amidated peptide that was first isolated 20 years ago from an ovine hypothalamic extract …
α-amidated peptide that was first isolated 20 years ago from an ovine hypothalamic extract …
The developmental neurobiology of autism spectrum disorder
E DiCicco-Bloom, C Lord, L Zwaigenbaum… - Journal of …, 2006 - Soc Neuroscience
1Departments of Neuroscience and Cell Biology and Pediatrics (Neurology), Robert Wood
Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway …
Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway …
The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis
The mechanisms that regulate the growth of the brain remain unclear. We show that Sonic
hedgehog (Shh) is expressed in a layer-specific manner in the perinatal mouse neocortex …
hedgehog (Shh) is expressed in a layer-specific manner in the perinatal mouse neocortex …
cAMP/PKA signalling reinforces the LATS–YAP pathway to fully suppress YAP in response to actin cytoskeletal changes
Actin cytoskeletal damage induces inactivation of the oncoprotein YAP (Yes‐associated
protein). It is known that the serine/threonine kinase LATS (large tumour suppressor) …
protein). It is known that the serine/threonine kinase LATS (large tumour suppressor) …
Endogenously produced neurotrophins regulate survival and differentiation of cortical progenitors via distinct signaling pathways
F Barnabé-Heider, FD Miller - Journal of Neuroscience, 2003 - Soc Neuroscience
Cultured embryonic cortical progenitor cells will mimic the temporal differentiation pattern
observed in vivo, producing neurons first and then glia. Here, we investigated the role of two …
observed in vivo, producing neurons first and then glia. Here, we investigated the role of two …
Hedgehog–Gli signaling and the growth of the brain
A Ruiz i Altaba, V Palma, N Dahmane - Nature Reviews Neuroscience, 2002 - nature.com
The development of the vertebrate brain involves the creation of many cell types in precise
locations and at precise times, followed by the formation of functional connections. To …
locations and at precise times, followed by the formation of functional connections. To …
Identification of neuropeptide-like protein gene families in Caenorhabditis elegans and other species
AN Nathoo, RA Moeller… - Proceedings of the …, 2001 - National Acad Sciences
Neuropeptides play critical roles in synaptic signaling in all nervous systems. Unlike
classical neurotransmitters, peptidergic neurotransmitters are encoded as preproproteins …
classical neurotransmitters, peptidergic neurotransmitters are encoded as preproproteins …
Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding
MA Kingsbury, SK Rehen, JJA Contos… - Nature …, 2003 - nature.com
Lysophosphatidic acid (LPA) is a phospholipid that has extracellular signaling properties
mediated by G protein–coupled receptors. Two LPA receptors, LPA1 and LPA2, are …
mediated by G protein–coupled receptors. Two LPA receptors, LPA1 and LPA2, are …
Glucose-dependent insulinotropic polypeptide is expressed in adult hippocampus and induces progenitor cell proliferation
J Nyberg, MF Anderson, B Meister… - Journal of …, 2005 - Soc Neuroscience
The hippocampal dentate gyrus (DG) is an area of active proliferation and neurogenesis
within the adult brain. The molecular events controlling adult cell genesis in the …
within the adult brain. The molecular events controlling adult cell genesis in the …
Insulin-like growth factor-1 promotes G1/S cell cycle progression through bidirectional regulation of cyclins and cyclin-dependent kinase inhibitors via the …
G Mairet-Coello, A Tury… - Journal of …, 2009 - Soc Neuroscience
Although survival-promoting effects of insulin-like growth factor-1 (IGF-1) during
neurogenesis are well characterized, mitogenic effects remain less well substantiated. Here …
neurogenesis are well characterized, mitogenic effects remain less well substantiated. Here …