Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 38-amino acid C-terminally
α-amidated peptide that was first isolated 20 years ago from an ovine hypothalamic extract …

1Departments of Neuroscience and Cell Biology and Pediatrics (Neurology), Robert Wood
Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway …

The mechanisms that regulate the growth of the brain remain unclear. We show that Sonic
hedgehog (Shh) is expressed in a layer-specific manner in the perinatal mouse neocortex …

Actin cytoskeletal damage induces inactivation of the oncoprotein YAP (Yes‐associated
protein). It is known that the serine/threonine kinase LATS (large tumour suppressor) …

Cultured embryonic cortical progenitor cells will mimic the temporal differentiation pattern
observed in vivo, producing neurons first and then glia. Here, we investigated the role of two …

The development of the vertebrate brain involves the creation of many cell types in precise
locations and at precise times, followed by the formation of functional connections. To …

Neuropeptides play critical roles in synaptic signaling in all nervous systems. Unlike
classical neurotransmitters, peptidergic neurotransmitters are encoded as preproproteins …

Lysophosphatidic acid (LPA) is a phospholipid that has extracellular signaling properties
mediated by G protein–coupled receptors. Two LPA receptors, LPA1 and LPA2, are …

The hippocampal dentate gyrus (DG) is an area of active proliferation and neurogenesis
within the adult brain. The molecular events controlling adult cell genesis in the …

Although survival-promoting effects of insulin-like growth factor-1 (IGF-1) during
neurogenesis are well characterized, mitogenic effects remain less well substantiated. Here …