Research status and prospect of non-viral vectors based on siRNA: a review

L Tong, D Liu, Z Cao, N Zheng, C Mao, S Liu… - International journal of …, 2023 - mdpi.com
Gene therapy has attracted much attention because of its unique mechanism of action, non-
toxicity, and good tolerance, which can kill cancer cells without damaging healthy tissues …

Non-coding RNAs as skin disease biomarkers, molecular signatures, and therapeutic targets

A Roso-Mares, I Andújar, T Díaz Corpas, BK Sun - Human Genetics, 2024 - Springer
Non-coding RNAs (ncRNAs) are emerging as biomarkers, molecular signatures, and
therapeutic tools and targets for diseases. In this review, we focus specifically on skin …

H3K9 trimethylation dictates neuronal ferroptosis through repressing Tfr1

T Lan, L Hu, T Sun, X Wang, Z Xiao… - Journal of Cerebral …, 2023 - journals.sagepub.com
Spontaneous intracerebral hemorrhage (ICH) is a devastating disease with high morbidity
and mortality worldwide. We have previously shown that ferroptosis contributes to neuronal …

Recent advances in the intracellular delivery of macromolecule therapeutics

SY Chen, XX Xu, X Li, NB Yi, SZ Li, XC Xiang… - Biomaterials …, 2022 - pubs.rsc.org
Intracellular delivery of macromolecules is a critical procedure for biological research and
drug discovery, including proteins, peptides, vaccines, antibodies and genes. The …

Principle, application and challenges of development siRNA-based therapeutics against bacterial and viral infections: a comprehensive review

H Motamedi, MM Ari, A Alvandi, R Abiri - Frontiers in Microbiology, 2024 - frontiersin.org
While significant progress has been made in understanding and applying gene silencing
mechanisms and the treatment of human diseases, there have been still several obstacles in …

基于RNA 干扰的杀菌剂开发及其对化学杀菌剂的影响

宋修仕, 高静, 周明国 - 农药学学报, 2023 - nyxxb.cn
RNA 干扰(RNA interference, RNAi) 是真核生物中高度保守的基因沉默现象,
在医药与植物保护领域展现出广阔的应用潜力, 相关产品已进入或即将进入医药与杀虫剂市场 …