The chemistry of hapalindoles, fischerindoles, ambiguines, and welwitindolinones

V Bhat, A Dave, JA MacKay, VH Rawal - The alkaloids: chemistry and …, 2014 - Elsevier
Isolated from diverse cyanobacteria, the hapalindole family of indole alkaloids comprises
over 80 interrelated natural products. The family is further divided into several subclasses …

Total Synthesis of Oxidized Welwitindolinones and (−)-N-Methylwelwitindolinone C Isonitrile

KW Quasdorf, AD Huters, MW Lodewyk… - Journal of the …, 2012 - ACS Publications
We report the total synthesis of (−)-N-methylwelwitindolinone C isonitrile, in addition to the
total syntheses of the 3-hydroxylated welwitindolinones. Our routes to these elusive natural …

Total Synthesis of (−)-N-Methylwelwitindolinone C Isothiocyanate

AD Huters, KW Quasdorf, ED Styduhar… - Journal of the American …, 2011 - ACS Publications
We report the first total synthesis of (−)-N-methylwelwitindolinone C isothiocyanate. Our
route features a number of key transformations, including an indolyne cyclization to …

Direct photo-induced reductive Heck cyclization of indoles for the efficient preparation of polycyclic indolinyl compounds

D Yu, WP To, Y Liu, LL Wu, T You, J Ling, CM Che - Chemical Science, 2021 - pubs.rsc.org
The photo-induced cleavage of C (sp2)–Cl bonds is an appealing synthetic tool in organic
synthesis, but usually requires the use of high UV light, photocatalysts and/or …

Total Synthesis of N-Methylwelwitindolinone D Isonitrile

V Bhat, KM Allan, VH Rawal - Journal of the American Chemical …, 2011 - ACS Publications
Described is a concise total synthesis of N-methylwelwitindolinone D isonitrile, the first in a
family of complex bicyclo [4.3. 1] decane-containing indole alkaloids to yield to synthesis …

Diastereoselective Synthesis of Cycloheptannelated Indoles via Lewis-Acid-Catalyzed (4+ 3)-Cyclization of Donor–Acceptor Cyclopropanes

BQ Li, ZW Qiu, AJ Ma, JB Peng, N Feng, JY Du… - Organic …, 2020 - ACS Publications
An efficient and straightforward Lewis-acid-mediated stereoselective (4+ 3)-cyclization of
indole-substituted alkylidene malonates and donor–acceptor cyclopropanes has been …

Total syntheses of the elusive welwitindolinones with bicyclo [4.3. 1] cores

AD Huters, ED Styduhar… - Angewandte Chemie …, 2012 - Wiley Online Library
Abstract The welwitindolinones with bicyclo [4.3. 1] cores are a class of natural products that
have attracted tremendous interest from the synthetic community because of their fascinating …

Total Synthesis of (−)-N-Methylwelwitindolinone B Isothiocyanate via a Chlorinative Oxabicycle Ring-Opening Strategy

NA Weires, ED Styduhar, EL Baker… - Journal of the American …, 2014 - ACS Publications
Total Synthesis of (−)-N-Methylwelwitindolinone B Isothiocyanate via a Chlorinative Oxabicycle
Ring-Opening Strategy | Journal of the American Chemical Society ACS ACS Publications …

A Unified Route to the Welwitindolinone Alkaloids: Total Syntheses of (−)-N-Methylwelwitindolinone C Isothiocyanate, (−)-N-Methylwelwitindolinone C Isonitrile, and (−)-3 …

KM Allan, K Kobayashi, VH Rawal - Journal of the American …, 2012 - ACS Publications
As part of a comprehensive strategy to the welwitindolinone alkaloids possessing a bicyclo
[4.3. 1] decane core, we report herein concise asymmetric total syntheses of (−)-N …

Formal syntheses of naturally occurring welwitindolinones

T Fu, WT McElroy, M Shamszad, SF Martin - Organic letters, 2012 - ACS Publications
The formal syntheses of N-methylwelwitindolinone C isothiocyanate, N-
methylwelwitindolinone C isonitrile, N-methylwelwitindolinone D isonitrile, 3-hydroxy-N …