Preparation of alginate-based biomaterials and their applications in biomedicine

H Zhang, J Cheng, Q Ao - Marine Drugs, 2021 - mdpi.com
Alginates are naturally occurring polysaccharides extracted from brown marine algae and
bacteria. Being biocompatible, biodegradable, non-toxic and easy to gel, alginates can be …

Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment

G Huang, F Li, X Zhao, Y Ma, Y Li, M Lin, G Jin… - Chemical …, 2017 - ACS Publications
The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

Advances in multicellular spheroids formation

X Cui, Y Hartanto, H Zhang - Journal of the Royal …, 2017 - royalsocietypublishing.org
Three-dimensional multicellular spheroids (MCSs) have a complex architectural structure,
dynamic cell–cell/cell–matrix interactions and bio-mimicking in vivo microenvironment. As a …

Alginate-based biomaterials for regenerative medicine applications

J Sun, H Tan - Materials, 2013 - mdpi.com
Alginate is a natural polysaccharide exhibiting excellent biocompatibility and
biodegradability, having many different applications in the field of biomedicine. Alginate is …

Injectable stem cell‐laden photocrosslinkable microspheres fabricated using microfluidics for rapid generation of osteogenic tissue constructs

X Zhao, S Liu, L Yildirimer, H Zhao… - Advanced Functional …, 2016 - Wiley Online Library
Direct injection is a minimally invasive method of stem cell transplantation for numerous
injuries and diseases. However, despite its promising potential, its clinical translation is …

Three‐dimensional models of cancer for pharmacology and cancer cell biology: capturing tumor complexity in vitro/ex vivo

JA Hickman, R Graeser, R de Hoogt… - Biotechnology …, 2014 - Wiley Online Library
Cancers are complex and heterogeneous pathological “organs” in a dynamic interplay with
their host. Models of human cancer in vitro, used in cancer biology and drug discovery, are …

Human pluripotent stem cell culture: considerations for maintenance, expansion, and therapeutics

KG Chen, BS Mallon, RDG McKay, PG Robey - Cell stem cell, 2014 - cell.com
Human pluripotent stem cells (hPSCs) provide powerful resources for application in
regenerative medicine and pharmaceutical development. In the past decade, various …

A fully defined and scalable 3D culture system for human pluripotent stem cell expansion and differentiation

Y Lei, DV Schaffer - … of the National Academy of Sciences, 2013 - National Acad Sciences
Human pluripotent stem cells (hPSCs), including human embryonic stem cells and induced
pluripotent stem cells, are promising for numerous biomedical applications, such as cell …

Process engineering of human pluripotent stem cells for clinical application

M Serra, C Brito, C Correia, PM Alves - Trends in biotechnology, 2012 - cell.com
Human pluripotent stem cells (hPSCs), including embryonic and induced pluripotent stem
cells, constitute an extremely attractive tool for cell therapy. However, flexible platforms for …

Advances in cell culture: anchorage dependence

OW Merten - … Transactions of the Royal Society B …, 2015 - royalsocietypublishing.org
Anchorage-dependent cells are of great interest for various biotechnological applications.(i)
They represent a formidable production means of viruses for vaccination purposes at very …