Autophagy and cancer drug resistance in dialogue: pre-clinical and clinical evidence

Y Qin, M Ashrafizadeh, V Mongiardini, B Grimaldi… - Cancer letters, 2023 - Elsevier
The emergence of drug resistance is a major challenge for oncologists. Resistance can be
categorized as acquired or intrinsic; the alteration of several biological mechanisms …

Long non-coding RNAs in lung cancer: Unraveling the molecular modulators of MAPK signaling

MS Hussain, O Afzal, G Gupta, ASA Altamimi… - … -Research and Practice, 2023 - Elsevier
Lung cancer (LC) continues to pose a significant global medical burden, necessitating a
comprehensive understanding of its molecular foundations to establish effective treatment …

Tumor hypoxia: From basic knowledge to therapeutic implications

C Liao, X Liu, C Zhang, Q Zhang - Seminars in cancer biology, 2023 - Elsevier
Diminished oxygen availability, termed hypoxia, within solid tumors is one of the most
common characteristics of cancer. Hypoxia shapes the landscape of the tumor …

[HTML][HTML] Progress in targeting PTEN/PI3K/Akt axis in glioblastoma therapy: Revisiting molecular interactions

M Hashemi, S Etemad, S Rezaei, S Ziaolhagh… - Biomedicine & …, 2023 - Elsevier
Glioblastoma (GBM) is one of the most malignant cancers of central nervous system and due
to its sensitive location, surgical resection has high risk and therefore, chemotherapy and …

Long non-coding RNAs (lncRNAs); roles in tumorigenesis and potentials as biomarkers in cancer diagnosis

S Najafi, SH Khatami, M Khorsand, Z Jamali… - Experimental cell …, 2022 - Elsevier
New research has indicated that long non-coding RNAs (lncRNAs) play critical roles in a
broad range of biological processes, including the pathogenesis of many complex human …

LncRNA in tumorigenesis of non-small-cell lung cancer: From bench to bedside

Q Hu, H Ma, H Chen, Z Zhang, Q Xue - Cell death discovery, 2022 - nature.com
Lung cancer has been one of the leading causes of cancer-related death worldwide, and
non-small-cell lung cancer (NSCLC) accounts for the majority of lung cancer morbidity, yet …

[HTML][HTML] SOX2 function in cancers: Association with growth, invasion, stemness and therapy response

S Mirzaei, MDA Paskeh, M Entezari… - Biomedicine & …, 2022 - Elsevier
Cancer is a leading cause of death worldwide and around 10 million deaths in 2020 were
related to cancer. There are a number of therapeutic modalities for cancer such as …

Exosome nanovesicles as potential biomarkers and immune checkpoint signaling modulators in lung cancer microenvironment: recent advances and emerging …

NA Khan, M Asim, KH Biswas, AN Alansari… - Journal of Experimental …, 2023 - Springer
Lung cancer remains the leading cause of cancer-related deaths globally, and the survival
rate remains low despite advances in diagnosis and treatment. The progression of lung …

Noncoding RNA as an influential epigenetic modulator with promising roles in cancer therapeutics

L Roy, O Chatterjee, D Bose, A Roy, S Chatterjee - Drug Discovery Today, 2023 - Elsevier
The epigenetic landscape has an important role in cellular homeostasis and its deregulation
leads to cancer. Noncoding (nc) RNA networks function as major regulators of cellular …

Liquid biopsy on the horizon in immunotherapy of non-small cell lung cancer: current status, challenges, and perspectives

Y Yang, H Liu, Y Chen, N Xiao, Z Zheng, H Liu… - Cell Death & …, 2023 - nature.com
Non-small cell lung cancer (NSCLC) is one of the most threatening malignancies to human
health and life. In most cases, patients with NSCLC are already at an advanced stage when …