Recent updates of diagnosis, pathophysiology, and treatment on osteoarthritis of the knee
S Jang, K Lee, JH Ju - International journal of molecular sciences, 2021 - mdpi.com
Osteoarthritis (OA) is a degenerative and chronic joint disease characterized by clinical
symptoms and distortion of joint tissues. It primarily damages joint cartilage, causing pain …
symptoms and distortion of joint tissues. It primarily damages joint cartilage, causing pain …
Subchondral bone microenvironment in osteoarthritis and pain
Y Hu, X Chen, S Wang, Y Jing, J Su - Bone research, 2021 - nature.com
Osteoarthritis comprises several joint disorders characterized by articular cartilage
degeneration and persistent pain, causing disability and economic burden. The incidence of …
degeneration and persistent pain, causing disability and economic burden. The incidence of …
Benefits and mechanisms of exercise training for knee osteoarthritis
CY Zeng, ZR Zhang, ZM Tang, FZ Hua - Frontiers in physiology, 2021 - frontiersin.org
Knee osteoarthritis is a chronic degenerative disease. Cartilage and subchondral bone
degeneration, as well as synovitis, are the main pathological changes associated with knee …
degeneration, as well as synovitis, are the main pathological changes associated with knee …
Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage–bone crosstalk
SR Goldring, MB Goldring - Nature Reviews Rheumatology, 2016 - nature.com
In diarthrodial joints, the articular cartilage, calcified cartilage, and subchondral cortical and
trabecular bone form a biocomposite—referred to as the osteochondral unit—that is …
trabecular bone form a biocomposite—referred to as the osteochondral unit—that is …
Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain
Joint pain is the defining symptom of osteoarthritis (OA) but its origin and mechanisms
remain unclear. Here, we investigated an unprecedented role of osteoclast-initiated …
remain unclear. Here, we investigated an unprecedented role of osteoclast-initiated …
Mechanisms of osteoarthritis (OA) pain
TW O'Neill, DT Felson - Current osteoporosis reports, 2018 - Springer
Abstract Purpose of Review Osteoarthritis (OA) is a major cause of pain and disability
worldwide. There is, however, a relatively poor correlation between the severity of OA based …
worldwide. There is, however, a relatively poor correlation between the severity of OA based …
Osteoarthritis: an update with relevance for clinical practice
JWJ Bijlsma, F Berenbaum, FPJG Lafeber - The Lancet, 2011 - thelancet.com
Osteoarthritis is thought to be the most prevalent chronic joint disease. The incidence of
osteoarthritis is rising because of the ageing population and the epidemic of obesity. Pain …
osteoarthritis is rising because of the ageing population and the epidemic of obesity. Pain …
[HTML][HTML] Intraarticular injections (corticosteroid, hyaluronic acid, platelet rich plasma) for the knee osteoarthritis
E Ayhan, H Kesmezacar, I Akgun - World journal of orthopedics, 2014 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is a complex “whole joint” disease pursued by inflammatory mediators,
rather than purely a process of “wear and tear”. Besides cartilage degradation, synovitis …
rather than purely a process of “wear and tear”. Besides cartilage degradation, synovitis …
The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis
J Sellam, F Berenbaum - Nature Reviews Rheumatology, 2010 - nature.com
Osteoarthritis (OA), one of the most common rheumatic disorders, is characterized by
cartilage breakdown and by synovial inflammation that is directly linked to clinical symptoms …
cartilage breakdown and by synovial inflammation that is directly linked to clinical symptoms …
Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis
PI Mapp, DA Walsh - Nature Reviews Rheumatology, 2012 - nature.com
During osteoarthritis (OA), angiogenesis is increased in the synovium, osteophytes and
menisci and leads to ossification in osteophytes and the deep layers of articular cartilage …
menisci and leads to ossification in osteophytes and the deep layers of articular cartilage …