Dictyostelia are soil amoebae capable of extraordinary feats of survival, motility, chemotaxis,
and development. Characterised by their ability to transform from a single-celled organism …

ADP-ribosylation is the post translational modification of proteins catalysed by ADP-
ribosyltransferases (ARTs). ADP-ribosylation has been implicated in a wide variety of …

The depletion of the stratospheric ozone layer and the resulting increase in hazardous
ultraviolet-B (UV-B) radiation reaching the Earth are of major concern not only for terrestrial …

The efficacy of the widely used chemotherapeutic drug cisplatin is limited by the occurrence
of drug-resistant tumour cells. To fully exploit the potential of this drug in cancer therapy, it is …

Sphingosine-1-phosphate, a product of sphingomyelin degradation, is an important element
of signal transduction pathways that regulate cell proliferation and cell death. We have …

Cells of Dictyostelium discoideum are highly resistant to DNA damaging agents such as UV-
light, γ-radiation and chemicals. The genes encoding nucleotide excision repair (NER) and …

ABSTRACT ADP-ribosylation by ADP-ribosyltransferases (ARTs) has a well-established role
in DNA strand break repair by promoting enrichment of repair factors at damage sites …

Resistance to chemotherapy is a major obstacle for the treatment of cancer and a subject of
extensive research. Numerous mechanisms of drug resistance have been proposed, and …

A Dictyostelium discoideum mutant with a disruption in the sphingosine-1-phosphate (S-1-P)
lyase gene was obtained in an unbiased genetic analysis, using random insertional …

Dynamic acetylation of all lysine-4-trimethylated histone H3 is a complex phenomenon
involved in Immediate-early gene induction in metazoan eukaryotes. Higher eukaryotes …