The inositol 1, 4, 5-trisphosphate (InsP3) receptors (InsP3Rs) are a family of Ca2+ release
channels localized predominately in the endoplasmic reticulum of all cell types. They …

Fertilization calcium waves are introduced, and the evidence from which we can infer
general mechanisms of these waves is presented. The two main classes of hypotheses put …

Abstract Inositol 1, 4, 5‐trisphosphate (IP3) is a second messenger that induces the release
of Ca2+ from the endoplasmic reticulum (ER). The IP3 receptor (IP3R) was discovered as a …

▪ Abstract The inositol 1, 4, 5 trisphosphate (IP3) receptor (IP3R) is a Ca2+ release channel
that responds to the second messenger IP3. Exquisite modulation of intracellular Ca2+ …

A centrally important factor in initiating egg activation at fertilization is a rise in free Ca2+ in
the egg cytosol. In echinoderm, ascidian, and vertebrate eggs, the Ca2+ rise occurs as a …

Abstract IP 3 receptor (IP 3 R) was found to release Ca 2+ from non-mitochondrial store but
the exact localization and the mode of action of IP 3 remained a mystery. IP 3 R was …

The transition from mature oocyte to developing embryo requires a coordinated series of
events, collectively known as egg activation. Egg activation includes changes to egg …

Calcium (Ca2+) signals initiate egg activation across the animal kingdom and in at least
some plants. These signals are crucial for the success of development and, in the case of …

Human bone marrow-derived mesenchymal stem cells (hMSCs) have the potential to
differentiate into several types of cells. Calcium ions (Ca2+) play an important role in the …

Background Neuronal activity alters calcium ion (Ca 2+) dynamics in astrocytes, but the
physiologic relevance of these changes is controversial. To examine this issue further, we …