Abstract Background and Aims The proportion of untreated patients with alcohol use
disorder (AUD) exceeds that of any other mental health disorder, and treatment alternatives …

This review describes and discusses studies related to reduced-risk drinking as an
additional treatment option for patients with problematic alcohol use and alcohol …

BACKGROUND: There is a large treatment gap in alcohol dependence, and current
treatments are only moderately effective in preventing relapse. New treatment modalities …

This study evaluated the efficacy of as-needed use of the opioid system modulator
nalmefene in reducing alcohol consumption in patients with alcohol dependence. Seven …

This study evaluated the long-term efficacy and safety of nalmefene treatment in reducing
alcohol consumption. We randomised (1: 3) 675 alcohol-dependent patients≥ 18 years of …

Background Alcohol dependence (AD) carries a high mortality burden, which may be
mitigated by reduced alcohol consumption. We conducted a systematic literature review and …

Background and aims Controlled drinking (CD) is an attractive treatment goal for a large
proportion of individuals with alcohol use disorder (AUD), but the availability of treatment …

Objective: Natural recovery and treatment outcome studies published over the past four
decades indicate that some individuals with substance use problems moderate their …

Background Digital self-help interventions for reducing the use of alcohol tobacco and other
drugs (ATOD) have generally shown positive but small effects in controlling substance use …

Objective: It is well known to clinicians and researchers in the field of alcoholism that
patients vary with respect to drinking goal. The objective in this study was to elucidate the …