Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Background: The global epidemiology of end-stage kidney disease (ESKD) reflects each
nation's unique genetic, environmental, lifestyle, and sociodemographic characteristics. The …

* These authors contributed equally to this work. A joint project by the American Society of
Nephrology (ASN), European Renal Association–European Dialysis and Transplant …

Surgical delays cannot be avoided in patients unfit for surgery at the time of admission
because of poor health status, severe comorbidities, or previous medication. Some …

Regular screening for the early detection of common chronic diseases might benefit from the
use of deep-learning approaches, particularly in resource-poor or remote settings. Here we …

The last quarter century witnessed significant population growth, aging, and major changes
in epidemiologic trends, which may have shaped the state of chronic kidney disease (CKD) …

Fibrosis is the final common pathway leading to end-stage renal failure. By analyzing the
kidneys of patients and animal models with fibrosis, we observed a significant mitochondrial …

Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …

Kidney disease has been described as the most neglected chronic disease. Reliable
estimates of the global burden of kidney disease require more population-based studies, but …

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