This digest covers some of the most relevant progress in malaria drug discovery published
between 2010 and 2012. There is an urgent need to develop new antimalarial drugs. Such …

Within the vast landscape of histone modifications lysine methylation has gained increasing
attention because of its profound regulatory potential. The methylation of lysine residues on …

Epigenetic dysregulation, which leads to the alteration of gene expression in the brain, is
suggested as one of the key pathophysiological bases of ageing and neurodegeneration …

Activity-based protein profiling (ABPP) has become an emerging chemical proteomic
approach to illustrate the interaction mechanisms between compounds and proteins. This …

Babesiosis is a malaria-like disease in humans and animals that is caused by Babesia
species, which are tick-transmitted apicomplexan pathogens. Babesia duncani causes …

Malaria relapses, resulting from the activation of quiescent hepatic hypnozoites of
Plasmodium vivax and Plasmodium ovale, hinder global efforts to control and eliminate …

Phenotypic variation in genetically identical malaria parasites is an emerging topic. Although
antigenic variation is only part of a more global parasite strategy to create adaptation …

There are pronounced interindividual variations in drug metabolism, drug responses, and
the incidence of adverse drug reactions. To a certain extent such variability can be …

The formation of reactive oxygen species (ROS) is a well-documented process in noise-
induced hearing loss (NIHL). We have also previously shown that activation of 5'adenosine …

Post-translational modifications play crucial parts in regulating protein function and thereby
control several fundamental aspects of eukaryotic biology, including cell signalling, protein …