The loss of control over drug intake that occurs in addiction was initially believed to result
from disruption of subcortical reward circuits. However, imaging studies in addictive …

Neuroimaging techniques are starting to reveal significant overlap in the brain circuitry
underlying addiction and disorders of dyscontrol over rewarding behaviors (such as binge …

The ability to predict relapse is a major goal of drug addiction research. Clinical and
diagnostic measures are useful in this regard, but these measures do not fully and …

The opioid system regulates affective processing, including pain, pleasure, and reward.
Restricting the role of this system to hedonic modulation may be an underestimation …

Background Sublingual formulations of buprenorphine (BUP) and BUP/naloxone have well-
established pharmacokinetic and pharmacodynamic profiles, and are safe and effective for …

BACKGROUND: We aimed to demonstrate a pharmacologically stimulated endogenous
opioid release in the living human brain by evaluating the effects of amphetamine …

Loss of inhibitory control over appetitively motivated behavior occurs in multiple psychiatric
disorders, including drug abuse, behavioral addictions, and eating disorders with binge …

Pathological gambling is a psychiatric disorder and the first recognized behavioral addiction,
with similarities to substance use disorders but without the confounding effects of drug …

Positron emission tomography (PET) is a molecular imaging modality that enables in vivo
exploration of metabolic processes and especially the pharmacology of neuroreceptors. G …

In the last decade, there has been an upsurge of interest in understanding the mechanisms
of behavior change (MOBC) and effective behavioral interventions as a strategy to improve …