Rapid and accurate profiling of infection-causing pathogens remains a significant challenge
in modern health care. Despite advances in molecular diagnostic techniques, blood culture …

Background Bloodstream infection (BSI) is a major public health burden worldwide, with
high mortality. Patient outcome is critically influenced by delayed therapy, and fast and …

ABSTRACT rRNA gene Sanger sequencing is being used for the identification of cultured
pathogens. A new diagnostic approach is sequencing of uncultured samples by using the …

BACKGROUND: Sepsis can lead to multiple organ failure and death. Timely and
appropriate treatment can reduce in-hospital mortality and morbidity. OBJECTIVES: To …

Fast microbiological diagnostics (MDx) are needed to ensure early targeted antimicrobial
treatment in sepsis. This systematic review focuses on the impact on antimicrobial …

Background When a bloodstream infection is suspected, the preliminary and definitive
results of culture-based microbiological testing arrive too late to have any influence on the …

Background Results of blood culture (BC) diagnostics should be swiftly available to guide
treatment of critically ill patients. Conventional BC diagnostics usually performs species …

Background: Sepsis from bacteremia occurs in 250,000 cases annually in the United States,
has a mortality rate as high as 60%, and is associated with a poorer prognosis than …

Background Rapid diagnosis and appropriate antimicrobial therapy are of major importance
to decrease morbidity and mortality in patients with blood stream infections (BSI). Blood …

Despite significant diagnostic and therapeutic improvements, infective endocarditis (IE) still
carries high morbidity and mortality. In the last three decades, significant variations in …