Daratumumab is a monoclonal antibody directed against the transmembrane glycoprotein
CD38 expressed on plasma cells and lymphoplasmocytes, with a proven efficacy in multiple …

The Ikaros zing-finger family transcription factors (IKZF TFs) are important regulators of
lymphocyte development and differentiation and are also highly expressed in B cell …

Abstract L‐Homophenylalanine (L‐HPA) is a vital building block for the synthesis of
numerous chiral drugs. However, the high cost of starting materials limits the industrial …

Pomalidomide (POM) has been discovered as a new molecular-glue-type degraders in
recent years. It is a potent immunomodulatory drug and is used for the treatment of …

Background Direct reductive amination of prochiral 2-oxo-4-phenylbutyric acid (2-OPBA)
catalyzed by phenylalanine dehydrogenase (PheDH) is highly attractive in the synthesis of …

Chimeric antigen receptor (CAR) T-cell therapy has shown remarkable successes in fighting
B-cell leukemias/lymphomas. Promising response rates are reported in patients treated with …

Multiple myeloma (MM), a cancer of plasma cells, is the second most common
hematological malignancy which is characterized by aberrant plasma cells infiltration in the …

We report successful clinical experience using anti-BCMA CAR-T combined with
lenalidomide in a patient who was refractory to a previous CAR-T treatment. The patient was …

The process of cancer initiation and development is regulated via the transcriptional
expression of cells going under genomic and epigenetic changes. Targeting epigenetic …

Cardiovascular diseases (CVDs), along with myocardial infarction and inflammatory heart
disease, account for the world's most expansive health concerns. Even though the …